Renal biopsy material from seven cases of the nephrotic syndrome due to focal glomerular sclerosis has been studied by light, electron, and immunofluorescent microscopy. The nature of glomerular basement membrane changes and the scar tissue was also studied. It was found that the glomerular basement membrane and mesangial matrix formed the major components of scar tissue. On the basis of a shor...

On rare occasions, patients with Goodpasture’s syndrome (GPS) present both anti-glomerular basement membrane (GBM) and antineutrophil cytoplasmic antibody (ANCA). Concurrent ANCA anti-GBM disease is a high mortality rate. Here we case of (ANCA) complicated hyponatremia.

The glycosaminoglycan (heparan sulfate) component of glomerular basement membranes from human kidneys of diabetic and nondiabetic subjects has been quantitated after isolation from protease digests of the membranes on DEAE-cellulose microcolumns. A significant decrease (P less than 0.005) in the glycosaminoglycan content of diabetic membranes was observed. Heparan sulfate was identified as the ...

1. Lysosomal proteinase activity was assayed in human cadaver kidney, urine, granules from poly­ morphonuclear leucocytes of normal persons, and urine samples from 154 patients with renal disease. 2. Granules from polymorphonuclear leuco­ cytes showed proteinase activity at acid and neutral pH, whereas cadaver kidney showed proteinase activity at acid pH only. 3. The urine from 13 patients with...

Anti-glomerular basement membrane disease is an extremely uncommon entity in children. It has incidence of 0.5 to 1 per million year adults and even more occurs due autoantibody against glomerular collagen characterized by rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. As the literature on anti-glomerular limited from our part world, it important consider as rare c...

Glomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glomerular basement membrane. The glomerular basement membranes of nephritic animals were observed to develop subepithelial extensions, "spikes." Although normally Type IV collagen is found throughout the full thickness of basement membranes, the "spikes" reacted with antibodies to laminin but not wi...

Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He require...

The negative charges of the sulfated glycosaminoglycans (GAGs) of the glomerular basement membrane (GBM) were differentially neutralized by perfusin with high molarity buffers in order to determine whether or not these charges protect the GBM from being clogged by circulating plasma macromolecules. Progressive elimination of the negative charges resulted in clogging of the GBM by perfused nativ...

Diffuse thickening of glomerular basement membranes (GBM) was optically observed in the renal grafts of 15 patients (21 specimens) among 70 recipients (128 specimens). Most of these specimens with diffuse GBM thickening were examined ultrastructurally. All cases with the above change were only found in allografts. The correlation was observed between the degree of GBM thickening and the clinica...