Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of OA. This review evaluates published studies of the effect of glucosamine salts and chondroitin sulfate preparations on the progression of knee or hip OA. Despite multiple double-blind, controll...

The properties of an N-acetyl-d-glucosamine-transport system have been studied by following the intracellular accumulation of methyl 2-acetamido-2-deoxy-alpha-d-[1-(14)C]glucoside by Escherichia coli. The same analogue was used to assay phosphoenolpyruvate phosphotransferase activity of toluene-treated cells. Transport and phosphorylation are induced by growth on d-glucosamine or N-acetyl-d-glu...

Kitin adalah homopolimer yang tersusun dari N-acetyl d-glucosamine dan glucosamine terikat dengan β 1–4 glycosidic . umumnya diperoleh ekstraksi kulit udang melalui proses deproteinasi demineralisasi tahapan lama panjang. Pada penelitian ini dilakukan isolasi kitin jamur tiram sebagai alternatif sumber bahan baku bantuan reaktor microwave Proses pada variasi waktu antara 5-60 menit untuk memper...

Glucosamine is a popular nutritional supplement used to treat osteoarthritis. Intravenous administration of glucosamine causes insulin resistance and endothelial dysfunction. However, rigorous clinical studies evaluating the safety of oral glucosamine with respect to metabolic and cardiovascular pathophysiology are lacking. Therefore, we conducted a randomized, placebo-controlled, double-blind,...

Fjelde et a!. (9) observed that D-glucosamine inhibited the growth of human epidermoid carcinoma cells in tissue culture, with concentration of 1 mg/mI causing death of the cells within 24 hr. The i.p. administration of divided doses of D-glucosamine or 2-deoxy-D-glucose inhibited the growth of Walker 256 carcinosarcoma in rats without significant toxicity to the host (1). Tumor growth resumed ...

To evaluate the role of the hexosamine biosynthesis pathway (HBP) in fat-induced insulin resistance, we examined whether fat-induced insulin resistance is additive to that induced by increased HBP flux via glucosamine infusion and, if so, whether such additive effects correlate with muscle HBP product levels. Prolonged hyperinsulinemic (approximately 550 pmol/l) euglycemic clamps were conducted...

BACKGROUND Degenerative Joint Disease (DJD) is the most common joint disease in human beings. Previous studies have explained that glucosamine is preferred as placebo and in efficacy compared with NSAID's in treatment of patients' knee osteoarthritis. Alendronate was used to treat osteoporotic patients and its efficacy was established. OBJECTIVES The aim of this study was to compare the effic...

The investigation of disease-modifying treatment options for osteoarthritis (OA) has become an important aspect of orthopaedic care. The purpose of this review is to critically evaluate the evidence for the use of glucosamine and chondroitin sulfate for knee OA with the goal of elucidating their indications for clinical use. The published clinical studies of glucosamine and chondroitin sulfate ...

Glucosamine is an amino sugar molecule used by many people to relieve the pain, discomfort, and progression of osteoarthritis. The benefit of using glucosamine to treat osteoarthritis has been supported by several clinical trials. However, it is noted not all clinical trials using glucosamine have been consistent. This article starts by discussing what osteoarthritis and glucosamine are. The ar...