Imbalanced hepatic glucose homeostasis is one of the critical pathologic events in the development of metabolic syndromes (MSs). Therefore, regulation of imbalanced hepatic glucose homeostasis is important in drug development for MS treatment. In this review, we discuss the major targets that regulate hepatic glucose homeostasis in human physiologic and pathophysiologic processes, involving hep...

Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways. Whole-animal physiology, islet studies and live-β-cell imaging approaches reveal that ablation of the kinase/phosphatase anchoring protein AKAP150 impairs insulin...

BACKGROUND Coplanar polychlorinated biphenyls (PCBs) promote adipocyte inflammation and impair glucose homeostasis in lean mice. The diabetes-promoting effects of lipophilic PCBs have been observed only during weight loss in obese mice. The molecular mechanisms linking PCB exposures to impaired glucose metabolism are unclear. OBJECTIVES In this study we tested the hypothesis that coplanar PCB...

: Heatwave events occur more frequently, accompanied by a significant increase in the ambient concentration of fine particulate matter (PM2.5). Epidemiological and experimental studies have suggested that heat stress or PM2.5 exposure would impair glucose homeostasis insulin sensitivity. To explore joint effects on metabolism hepatic pathway. C57BL/6 mice were randomly divided into filtered air...

Glucose homeostasis is maintained through interplay between central and peripheral control mechanisms which are aimed at storing excess glucose following meals and mobilizing these same stores during periods of fasting. The nucleus of the solitary tract (NST) in the dorsal medulla has long been associated with the central detection of glucose availability and the control of glucose homeostasis....

Glucose Homeostasis and the Metabolic Syndrome Glucose homeostasis represents the outcome of a complex feedback system for maintaining glucose tolerance within rather narrow physiological limits. Aberrant glucose homeostasis contributes to a number of downstream effects, including insulin resistance. Insulin resistance occurs when muscle, fat, or liver does not appropriately use the insulin tha...

Glucose Homeostasis and the Metabolic Syndrome Glucose homeostasis represents the outcome of a complex feedback system for maintaining glucose tolerance within rather narrow physiological limits. Aberrant glucose homeostasis contributes to a number of downstream effects, including insulin resistance. Insulin resistance occurs when muscle, fat, or liver does not appropriately use the insulin tha...

Glucose Homeostasis and the Metabolic Syndrome Glucose homeostasis represents the outcome of a complex feedback system for maintaining glucose tolerance within rather narrow physiological limits. Aberrant glucose homeostasis contributes to a number of downstream effects, including insulin resistance. Insulin resistance occurs when muscle, fat, or liver does not appropriately use the insulin tha...