Subcellular fractionation of rat cerebral cortical slices on sucrose density gradients provides evidence for the existence of a unique synaptosomal fraction (enriched in pinched-off nerve endings) that selectively accumulates glutamic and aspartic acids. The particles in this fraction sediment to a less dense portion of sucrose gradients than do particles that accumulate aromatic, basic, and ne...

In previous investigations it was shown that in folic acid deficiency there is a large increase in the urinary excretion of formimino-n-glutamic acid (l-6). This increase has been explained by recent enzymatic studies demonstrating that the first step in the metabolism of formimino+glutamic acid is the transfer of the formimino group to tetrahydrofolic acid (7-9). Formimino-n-glutamic acid is a...

BACKGROUND L-glutamic acid is one of the major amino acids that is present in a wide variety of foods. It is mainly used as a food additive and flavor enhancer in the form of sodium salt. Corynebacterium glutamicum (C. glutamicum) is one of the major organisms widely used for glutamic acid production. METHODS The study was dealing with immobilization of C. glutamicum and mixed culture of C. g...