INTRODUCTION Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats. MATERIAL AND METHODS Forty Wistar rats were randomly assigned to four groups (n = 10 e...

The aim of this study was to document the haematological profile of pregnant ewes throughout gestation. Sheep were divided into three groups (n = 8 per group): non-pregnant, singleton, or twin pregnancy. Blood samples were collected every 14 days from day 55 of gestation for haemoglobin concentration; packed cell volume; total protein; and albumin concentration. On days 55 and 125 of gestation ...

Ethanol metabolites may directly or indirectly induce oxidative stress as a result of disturbed balance between proand antioxidative processes. An indirect effect of ethanol on the generation of oxidative stress is associated with the attenuation of intracellular defensive enzymatic antioxidants, e.g. gluthatione peroxidase, catalase, superoxide dismutase as well as waterand/or fat-soluble low-...

Following the previous examinations on lipid peroxide (LPO) and related enzyme activities in male SHR and SHRSP (Jap Heart J 18: 608, 1977), further studies were conducted with both male and female SHR, SHRSP, and WKR. LPO in tissue homogenate or serum pretreated with sodium dodecyl sulfate (SDS) was measured by colorimetric (OD532nm) and/or fluorometric (Ex515nm, Em555nm) method according to M...

1. The progression of Heinz body anaemia was studied in groups of lambs of low- and high-copper status, produced through breeding or Cu supplementation, when they were transferred from improved pasture to rape (Brassica napus L.) in autumn. Some lambs had previously received selenium by injection. The Cu and Se supplements markedly increased superoxide dismutase (EC 1.15.1.1; SOD) and glutathio...

BACKGROUND Adriamycin (ADR) is an effective chemotherapeutic agent against cancers but its clinical use is limited due to its cardiotoxicity. It has been suggested that the pathogenesis involves inhibition of nucleic acid and protein synthesis, free radical formation and lipid peroxidation. Schisandra (SC) has strong antioxidant activity. We investigate the protective effects of SC on adriamyci...

Lipid peroxidation (LPO) is a free radical-related process that in biologic systems may occur under enzymatic control, e.g., for the generation of lipid-derived inflammatory mediators, or nonenzymatically. This latter form is associated mostly with cellular damage as a result of oxidative stress, which also involves cellular antioxidants in this process. This article focuses on the relevance of...

BACKGROUND AND PURPOSE The usefulness of Bleomycin (BLM) as an important antineoplastic drug is usually limited to the development of dose and time-dependent interstitial pneumonitis and pulmonary fibrosis. This study has been initiated to investigate the possible protective effects of acetyl-L-carnitine (AC) against BLM-induced lung toxicity at an early stage of its development. MATERIAL AND...

Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide on the small intestine mucositis induced by methotrexate (MTX) in rats. Experimental animals were divided into the control group, MTX group (MTXG) and nimesulide+MTX administ...

introduction : pemphigus comprises a group of diseases characterized by cutaneous and mucosal blistering. pemphigus vulgaris (pv) is the most common and important variant. recent reports have revealed the relatively high incidence of pv in iran. the onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of the several factors responsible f...