objective(s):glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. glutathione s-transferases (gsts) are members of multigenic family, which have important role in cells as an antioxidant. in the present study, we examined the polymorphism of gstt1 and gstm1 deletion genotypes (t0m1, t1m0, and t0m0) in 100 glaucoma patients (41with pr...

Glutathione S-transferase activity has been shown to be firmly associated with microsomal fractions. This activity could not be removed by repeated washing, by sonication, or by treatment of the microsomal fractions with high salt concentrations or urea. Treatment of the microsomal fraction with puromycin and MgCls to remove the ribosomes with any associated newly synthesized proteins did not d...

Background: Glutathione S-transferases (GSTs) are detoxifying enzymes that contribute to the glutathione-ascorbic acid (vitamin C) antioxidant cycle. Objective: The objective was to determine whether GST genotypes modify the association between dietary vitamin C and serum ascor-

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...

The purification of homogeneous glutathione S-transferases B and C from rat liver is described. Kinetic and physical properties of these enzymes are compared with those of homogeneous transferases A and E. The letter designations for the transferases are based on the reverse order of elution from carboxymethylcellulose, the purification step in which the transferases are separated from each oth...

The purification of homogeneous glutathione S-transferases B and C from rat liver is described. Kinetic and physical properties of these enzymes are compared with those of homogeneous transferases A and E. The letter designations for the transferases are based on the reverse order of elution from carboxymethylcellulose, the purification step in which the transferases are separated from each oth...