Glyceryl ether monooxygenase is a tetrahydrobiopterin-dependent membrane-bound enzyme which catalyses the cleavage of lipid ethers into glycerol and the corresponding aldehyde. Despite many different characterisation and purification attempts, so far no gene and primary sequence have been assigned to this enzyme. The seven other tetrahydrobiopterin-dependent enzymes can be divided in the family...

BACKGROUND Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS To study the effect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using a randomi...

OBJECTIVE To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. DESIGN Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. SETTING Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. SUBJ...

Objective—To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. Design—Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. Setting—Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. Subjects—6...

Non ionic surfactant vesicles (niosomes) composed of sorbitan monostearate (Span 60), polyoxyethylene sorbitan monostearate (Tween 61), cholesterol, and dicetyl phosphate were conjugated with a purified monoclonal antibody to CD44 (IM7) through a cyanuric chloride (CC) linkage on the polyoxyethylene group of the Tween 61 molecule. Inclusion of small amounts of Tween 61 within the surfactant com...

OBJECTIVE To investigate whether the susceptibility to tolerance to glyceryl trinitrate is similar in different vascular beds in patients with chronic heart failure. PATIENTS Twenty patients with heart failure underwent a continuous infusion of glyceryl trinitrate over 24 hours followed by administration of N-acetylcysteine (5 g intravenously) in a bolus. MAIN OUTCOME MEASURES Haemodynamic ...

Platelet-activating factor is a novel phospholipid that has been implicated as an important mediator of acute allergic reactions. The intravenous administration of acetyl glyceryl ether phosphorylcholine, a pure, synthetic platelet-activating factor, causes electrocardiographic changes in the rabbit similar to those which are characteristic manifestations of systemic anaphylaxis. To determine w...

OBJECTIVE To determine the optimum conditions for the demonstration of an antiplatelet effect of nitric oxide and to use these conditions to elucidate the effects of a transdermal glyceryl trinitrate patch on platelet aggregation in normal volunteers. METHODS An open prospective crossover study. The effects of nitric oxide on platelet aggregation in whole blood and platelet rich plasma as sti...

Bread is a food made from wheat flour which can be used as an alternative substitute. Wheat still imported. Therefore, one way to reduce the increase in import numbers by using local ingredients that raw materials for making white bread. Local are cassava tubers, kimpul uwi tubers. The use of bread add variety and value purpose this study was determine effect proportions tuber addition glycerol...

Priapism is a prolonged penile erection without sexual stimulation. Two forms of priapism are recognized: veno-occlusive or low-flow priapism and arterial or high-flow priapism. High-flow (arterial) priapism is usually the result of straddle injury. Treatment of high-flow priapism may be elective Low-flow priapism is usually related to sickle cell disease, haemoglobinopathies, neoplastic syndro...