The ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification C3 convertase is independent of antithrombin binding activity and requires substitution of the amino sugar and a degree of oxygen (O)-sulfation which could be on the uronic acid or the amino sugar. Preparations of heparin glycosaminoglycan isolated by different techniques from different speci...

In the present study, phage display-derived antibodies were used to investigate the topology of glycosaminoglycan epitopes in the diaphragm of chronic obstructive pulmonary disease (COPD) and non-COPD patients. Furthermore, the potential physiological significance of changes in the occurrence of glycosaminoglycan epitopes in the diaphragm of COPD patients was studied by determining the overlap ...

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The practical effectiveness of Thm. A.1 is roughly commensurate with the difficulty of its proof. That is, the proof is essentially trivial, and the condition is nearly useless. There are very few problems where simple pointwise minimization of the integrand at every instant yields an arc that is even admissible, much less optimal! Even worse, we have met many true minimizers (often in problems...