ABSTRACTBackground : In order to quantify effects of ultrasound irradiation parameters under therapeutic condition, especially sonodynamic therapy, it is initially necessary to evaluate inertial cavitation activity in vitro conditions therefore, in this study, the effect of 1 MHz low level ultrasound based on °OH radicals generated by acoustic inertial cavitation in aqueous solution was monit...

Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetration. Mechanical disruption of the stroma can be achieved using ultrasound-induced bubble activity-cavitation. Cavitation is also known to resul...

Sonophoresis can increase skin permeability to various drugs in transdermal drug delivery. Cavitation is recognized as the predominant mechanism of sonophoresis. Recently, a new logical approach to enhance the efficiency of transdermal drug delivery was tried. It is to utilize the engineered microbubble and its resonant frequency for increase of cavitation activity. Actively-induced cavitation ...

Background: Antibody-drug conjugates (ADCs) are a new class of antitumor agents that combine the targeting specificity monoclonal antibodies (mAbs) with cell killing ability powerful cytotoxic molecules. However, poor penetration drugs into solid tumors, including mAbs, is well-recognized barrier to effective therapy as this strongly limits number tumor cells targeted by therapeutic agent. A no...

Thermal ablation by High Intensity Focused Ultrasound (HIFU) is the only technique for noninvasive treatment of tumours, but suffers from a long treatment times and varied treatment outcomes. Knowledge of the nonlinear parameter B/A can resolve these by improving treatment planning, and correlation between enhanced nonlinear signals and the presence of HIFU lesions has the potential to monitor ...

Diagnostic ultrasound contrast agents have been developed for enhancing the echogenicity of blood and for delineating other structures of the body. Approved agents are suspensions of gas bodies (stabilized microbubbles), which have been designed for persistence in the circulation and strong echo return for imaging. The interaction of ultrasound pulses with these gas bodies is a form of acoustic...

OBJECTIVE The ability of ultrasound (US) and ultrasound contrast agents (UCAs) to induce angiogenesis has been explored as a means of restoring blood flow to ischemic muscle. Because UCAs demonstrate an increasing percentage of collapse cavitation with increasing US pressure (Pr), this study sought to explore the effects of a US Pr that produces 100% collapse cavitation, determine the capillary...

Background: The prevalence of obesity increases in both developed and developing countries. Beside individuals have started to seek ways of changing their aesthetic appearance by easy methods. Objectives: This study was conducted in an attempt to identify the effect of methods performed through a device for regional weight loss on the regional fat mass and body composition to reduce regional fa...

background: essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. this study reports the in vitro cytotoxic effects of the essential oil from artemisia absinthium l. (asteraceae) growing wild in iran. methods: water-distilled essential oil of a. absinthium collected from ardabil, north-western iran, was examine...