Mutant mice exhibiting a growth retardation phenotype arose spontaneously in the inbred NC/Sgn mouse strain. The mode of inheritance of this mutation was autosomal recessive, and I named this mutation growth deficit (gd). The gd locus was mapped to the proximal part of chromosome 4, between microsatellite markers D4Mit139 and D4Mit178. Histologic abnormalities were detected in the mutant testis...

The application of microarray technology to the study of mammalian organogenesis can provide greater insights into the steps necessary to elicit a functionally competent tissue. To this end, a temporal profile of gene expression was generated with the purpose of identifying changes in gene expression occurring within the developing male and female embryonic gonad. Gonad tissue was collected fro...

Organ shape and size, and, ultimately, organ function, relate in part to the cell and tissue spatial arrangement that takes place during embryonic development. Despite great advances in the genetic regulatory networks responsible for tissue and organ development, it is not yet clearly understood how specific gene functions are linked to the specific morphogenetic processes underlying the intern...

The two parts of the Caenorhabditis elegans reproductive system, the germ cells and the somatic reproductive tissues, each influence the life span of the animal. Removing the germ cells increases longevity, and this life span extension requires the somatic gonad. Here we show that the somatic gonad and the germ cells make distinct contributions to life span determination. The life span increase...

The gonad index, GI, is widely used as a measure of changes in reproductive state. There are, however, problems with its use because it is based on the implicit assumption of an isometric relationship between gonad size and some measure of total size. If, for example, gonad weight and total weight are used, the exponent for an allometric relationship usually is ignored and hence assumed to be 1...

The presence of germ cells in the early gonad is important for sexual fate determination and gonadal development in vertebrates. Recent studies in zebrafish and medaka have shown that a lack of germ cells in the early gonad induces sex reversal in favor of a male phenotype. However, it is uncertain whether the gonadal somatic cells or the germ cells are predominant in determining gonadal fate i...

The Caenorhabditis elegans somatic gonad develops from a four-cell primordium into a mature organ that differs dramatically between the sexes in overall morphology (two arms in hermaphrodites and one in males) and in the cell types comprising it. Gonadal development in C. elegans is well studied, but regulation of sexual differentiation, especially later in gonadal development, remains poorly e...

Sexual reproduction of multicellular organisms depends critically on the coordinate development of the germ line and somatic gonad, a process known as gonadogenesis. Together these tissues ensure the formation of functional gametes and, in the female of many species, create a context for production and further development of the zygote. Since the future of the species hangs in the balance, it i...

The aim of this study was to determine the effects silver nanoparticles (AgNPs) on morphology and enzymatic activity butterfly splitfin (Ameca splendens). Individuals both sexes, aged about five months, were exposed AgNPs at concentrations 0 (control group), 0.01, 0.1, 1.0 mg/dm3 for 42 days. On last day experiment, fish euthanized, subjected standard histological processing (anterior intestine...

OBJECTIVE To determine whether gonad shields are correctly positioned on the pelvic radiographs of children with slipped capital femoral epiphysis. DESIGN Retrospective study of radiographs taken of children treated by in situ pinning of slipped capital femoral epiphysis between 1 January 1983 and 31 December 1988. SETTING Three teaching hospitals in north west England. PATIENTS 32 patien...