نتایج جستجو برای: gpia
تعداد نتایج: 74 فیلتر نتایج به سال:
چکیده سابقه و هدف سقط مکرر خودبهخودی، به ختم بارداری قبل از هفته 20 حاملگی اطلاق میشود. در برخی از زنان با سابقه سقط مکرر، جهشهای ژن ترومبوفیلیک منجر به ایجاد لختههای خونی در عروق جفت، کاهش اکسیژنرسانی و مرگ جنین میشود. هدف از این مطالعه، بررسی ارتباط پلیمورفیسمهای 807C/T (ژن GPIa) و pLA1/pLA2 (ژن GPIIIa) با سقط مکرر خودبهخودی بود. مواد و روشها در این مطالعه مورد - شاهدی، 50 خانم...
BACKGROUND AND PURPOSE Few genetic modifications have been identified to be associated with subarachnoid hemorrhage (SAH), most of them playing a role in the formation or size of aneurysms. METHODS We evaluated the role of common and functional polymorphisms affecting the main platelet adhesive glycoproteins (GP) (GPIIIa: HPA-1; GPIa: HPA-5 and C807T; GPIbalpha: HPA-2 and VNTR) in the risk fo...
Liposomes carrying both recombinant glycoprotein Ia/IIa (rGPIa/IIa) and Ib (rGPIb ) (rGPIa/IIa-Ib -liposomes) instantaneously and irreversibly adhered to the collagen surface in the presence of soluble von Willebrand factor (VWF) at high shear rates, in marked contrast with translocation of liposomes carrying rGPIb alone on the VWF surface. In the absence of soluble VWF, the adhesion of rGPIa/I...
In the present study, we show by adhesion assays and ultrastructural studies that platelets can bind to CD34+ cells from human blood and bone marrow and that this interaction interferes with the accurate detection of endogenously expressed platelet glycoproteins (GPs). The interaction between these cells was found to be reversible, dependent on divalent cations, and mediated by P-selectin. Enzy...
Platelets are heterogeneous in the content of membrane glycoprotein (GP)IIb/IIIa complex. To determine whether this heterogeneity is related to changes associated with platelet aging in the circulation, newly released platelets, obtained during recovery from nonimmune-mediated acute experimental thrombocytopenia in baboons, were studied. Monoclonal antibody (MoAb) binding to epitopes expressed ...
VLA-2 (also called gpIa/IIa on platelets) is a collagen receptor with a unique alpha subunit and a beta subunit common to other adhesion receptors in the VLA/integrin family. Multiple cDNA clones for the human VLA-2 alpha 2 subunit have been selected from a lambda gtll library by specific antibody screening. The 5,374-bp nucleotide sequence encoded for 1,181 amino acids, including a signal pept...
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