Each artery conduces blood (conduit function, CF) and smoothes out the pulsatility (buffering function, BF), while keeping its wall protected against the high oscillations of the pulse waves (damping function, xi). These functions depend on each segment viscoelasticity and capability to store and dissipate energy. When a graft/prosthesis is implanted, the physiological gradual transition in the...

Structural bone allografts are widely used in the clinic to treat critical sized bone defects, despite lacking the osteoinductive characteristics of live autografts. To address this, we generated revitalized structural allografts wrapped with mesenchymal stem/progenitor cell (MSC) sheets, which were produced by expanding primary syngenic bone marrow derived cells on temperature-responsive plate...

Introduction: Anterior cruciate ligament (ACL) reconstruction is one of the most widely performed orthopaedic procedures in developed counties. Reconstruction using autograft soft tissue such as hamstring tendon has been the preferred choice by many for its superior strength and less donor-site morbidity over the bone-tendon-bone graft. Fixation of soft tissue graft, however, has been less than...

Acellular xenogeneic tissues have the potential to provide 'off-the-shelf' grafts for anterior cruciate ligament (ACL) repair. To ensure that such grafts are sterile following packaging, it is desirable to use terminal sterilization methods. Here, the effects of gamma and electron beam irradiation on the biological and biomechanical properties of a previously developed acellular porcine superfl...

PURPOSE Interference fit fixation of soft-tissue grafts has recently raised strong interest because it allows for anatomic graft fixation that may increase knee stability and graft isometry. Although clinical data show promising results, no data exist on how tendon healing progresses using this fixation. The purpose of the present study was to investigate anterior cruciate ligament (ACL) recons...

Aim: Mesenchymal stem cells (MSCs) are an excellent potential source of cells for bone tissue engineering due to their excellent renewal ability and osteogenic differentiation capabilities. This study was designed to evaluate the bone formation properties of a demineralized cancellous bone scaffold seeded with MSCs, with or without periosteum, in a critical size bone defect model in rabbits. Me...

Advances in surgical technique and rehabilitation have resulted in marked improvement in the outcome of anterior cruciate ligament (ACL) reconstruction over the past 10 years. Most recent series approach a 90% success rate in terms of restoration of knee stability, patient satisfaction, and return to full athletic activity.1 The optimal graft material remains controversial, regardless of the gr...

Background: Hamstring and peroneus longus tendon auto graft has similar biomechanical strength. Peroneus is a potential in reconstructive orthopaedic procedures. There was few study evaluation of usage ACL reconstruction. We aimed to quantify the outcome donor site morbidity reconstruction using graft.Methods: Patients who suffered isolated injury were enrolled underwent trans-portal single bun...

BACKGROUND Although considerable efforts have been made to improve the graft patency in coronary artery bypass surgery, the role of biomechanical factors remains underrecognized. The aim of this study is to investigate the influences of geometric configurations of the bypass graft on hemodynamic characteristics in relation to anastomosis. MATERIALS AND METHODS The Numerical analysis focuses o...

Background: The anterior half of the peroneus longus tendon (AHPLT) has recently gained popularity to become alternate graft choice for cruciate ligament reconstruction due its acceptable biomechanical properties, easy and safe harvest. Methods: A retrospective study was conducted compare results (ACL) with AHPLT hamstring at minimum 3 years follow-up. Knee stability, International Documentatio...