INTRODUCTION Bacteremia is recognized as a critical condition that influences the outcome of sepsis. Although large-scale surveillance studies of bacterial species causing bacteremia have been published, the pathophysiological differences in bacteremias with different causative bacterial species remain unclear. The objective of the present study is to investigate the differences in pathophysiol...

BACKGROUND Several studies have investigated single nucleotide polymorphisms (SNPs) in candidate genes associated with sepsis and septic shock with conflicting results. Only few studies have combined the analysis of multiple SNPs in the same population. METHODS Clinical data and DNA from consecutive adult patients with culture proven Gram negative bacteremia admitted to a Danish hospital betw...

Because of its capacity to neutralize the lethality of gram-negative bacterial endotoxic lipopolysaccharides, PMX-622 (polymyxin B bound to dextran 70) is being developed for possible adjunctive therapy of gram-negative sepsis. In this study, it was determined that the in vitro antimicrobial activity of PMX-622 was minimal and that it does not interfere with the in vitro antimicrobial activity ...

Compounds with antiendotoxin properties have been extensively studied for their potential as therapeutic agents for sepsis attributable to gram-negative bacteria. However, with the increasing incidence of gram-positive sepsis, there is interest in identifying compounds with a broad spectrum of action against both gram-positive and gram-negative bacteria. A series of synthetic alpha-helical cati...

The Authors Reply We appreciate the interest and comments from Dr. Mustafa Hatipoglu et al. regarding our study (1). Their major concern is that Staphylococcus aureus (S. aureus) was not included in the Gram-positive cocci group for the comparison of the procalcitonin (PCT) levels between the patients with sepsis caused by Gram-positive cocci and that caused by Gram-negative rods. When we perfo...