Understanding tumor heterogeneity is an urgent and unmet need in cancer research. In this study, we used a morphology-based optical cell separation process to classify a heterogeneous cancer cell population into characteristic subpopulations. To classify the cell subpopulations, we assessed their morphology in hydrogel, a three-dimensional culture environment that induces morphological changes ...

BACKGROUND Granular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue. METHODS Seven patients were treated for granular cell tumors of the tongue at our institutio...

Background: The study determined the histological layers of cerebral cortex and hippocampus albino rat brain samples has been used in study. Cerebral is composed Molecular layer, external granular, pyramidal internal granular layer interior layer. are alveus, stratum oriens, pyramidale, radiatum, lacunosum moleculare. aim to analyze detailed features rats at magnification 10X,100X,40X. By using...

Most striated duct (SD) cells in the adult mouse parotid gland (PAG) have a few small secretory granules. These granules, however, are usually too small and sparse to be detected using light microscopy. Our serial studies have suggested that these PAG SD cells belong to a group of hormone-responsive granular duct cells, similar to the granular convoluted tubule (GCT) cells found in the submandi...

The authors present an interesting and unusual histology of compound odontoma from an 18-year-old female. Part of the subepithelial connective tissue beneath the enamel organ epithelium was replaced by a granular cell nodule, of a probable histiocytic nature. This case represents the first published report of odontoma accompanied by granular cells.

BACKGROUND Granular cell ameloblastoma is a rare histological subtype of ameloblastoma accounting for less than 5% of the total. The characteristic microscopic features of granular cells are attributed to the increased presence of lysosomes in the cytoplasm of the tumour cells. METHODS A case of bone expansion in the mandible of 65 year old patient was examined on the basis of the clinical ex...

Desmosomes in stratified squamous epithelia appear to exhibit quantitative alterations during differentiation. In this work we use stereological and other morphometric methods to quantify these structures in epithelial cells from defined basal, spinous and granular strata. Hamster cheek pouch mucosa from five animals was processed for electron microscopy using strictly standardized techniques a...

BACKGROUND Large granular lymphocyte leukemia is a semi-autonomous clonal proliferation of cytotoxic T cells accompanied by immune cytopenias and various autoimmune conditions. Due to the rarity of this disease and its association with autoimmune diseases, a theoretical germline or somatic mutation might have significant penetrance, thus enabling detection, even from samples of suboptimal size,...