Efficient gene regulation of metabolic pathways implies that the profile of molecules inducing the pathway matches that of the molecules that are metabolized. Gratuitous induction, a well-known phenomenon in catabolic pathways, is the consequence of differences in the substrate and inducer profiles. This phenomenon is particularly evident in pathways for biodegradation of organic contaminants t...

Bacterial dioxygenase systems are multicomponent enzymes that catalyze the initial degradation of many environmentally hazardous compounds. In Sphingopyxis granuli strain TFA tetralin dioxygenase hydroxylates tetralin, an organic contaminant. It consists of a ferredoxin reductase (ThnA4), a ferredoxin (ThnA3) and a oxygenase (ThnA1/ThnA2), forming a NAD(P)H-ThnA4-ThnA3-ThnA1/ThnA2 electron tran...

Transcription of the catabolic touABCDEF operon, encoding the toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1, is driven by the sigma(54)-dependent Ptou promoter, whose activity is controlled by the phenol-responsive NtrC-like activator TouR. In this paper we describe for the first time a peculiar characteristic of this system, namely, that Ptou transcription is activated in a growth...

The issue of increasing budgetary independence and security is relevant for the majority territorial systems, both at regional municipal levels. It was hypothesised that changes in structure public debt have a negative impact on their security. According to this hypothesis, an increase proportion bank borrowing corresponding decrease securities by constituent entities Russian Federation leads g...

abstract background: thalassemia major is the most common hereditary anemia in iran. thalassemia major patients require lifelong care and suffer much pain during self-care. knowledge of the nature, meaning, and impact of suffering from the perspective of patients is needed to determine which interventions are helpful. this study was designed to understand the experience of suffering in patients...