A key limitation in modern biology is the ability to rapidly identify genes underlying newly identified complex phenotypes. Genome wide association studies (GWAS) have become an increasingly important approach for dissecting natural variation by associating phenotypes with genotypes at a genome wide level. Recent work is showing that the Arabidopsis thaliana defense metabolite, allyl glucosinol...

Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE(-/-)) mice indicate that exacerbated tissue GSL accumulation resulting from alpha-galactosidase deficiency promotes atherosclerosis, whereas the serine palmitoyl transferase inhibitor myriocin (which reduces plasma and tissue levels of several sphingolipids, including sphingomy...

Glucosinolates (GSLs) are widely known secondary metabolites that have anticarcinogenic and antioxidative activities in humans and defense roles in plants of the Brassicaceae family. Some R2R3-type MYB (myeloblastosis) transcription factors (TFs) control GSL biosynthesis in Arabidopsis. However, studies on the MYB TFs involved in GSL biosynthesis in Brassica species are limited because of the c...

'Salt & Pepper' syndrome is an autosomal recessive condition characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation. High-density SNP array analysis performed on siblings first described with this syndrome detected four shared regions of loss of heterozygosity (LOH). Whole-exome sequencing narrowed the ca...

BACKGROUND Prior research on the microorganisms associated with the brine shrimp, Artemia franciscana, has mainly been limited to culture-based identification techniques or feeding studies for aquaculture. Our objective was to identify bacteria and archaea associated with Artemia adults and encysted embryos to understand the role of microbes in the Artemia life cycle and, therefore, their impor...

we investigate the growth of matter density perturbations as well as the generalized second law (gsl) of thermodynamics in the framework of f(r)-gravity. we consider a spatially flat frw universe filled with the pressureless matter and radiation which is enclosed by the dynamical apparent horizon with the hawking temperature. for some viable f(r) models containing the starobinsky, hu-sawicki, exp...

SUMMARY The Genetic Simulation Library (GSL) is a set of C++ programs and classes that can be used in individual-based simulation models of plant and animal populations. The classes in this library build representations of genes for a wide variety of different types of organisms, from asexually reproducing single-cell organisms to chromosome-structured sexually reproducing species. AVAILABILI...

Glucosinolates (GSLs) and cyanogenic glycosides (CGs) fulfil functions in plant defence have been reported to be anticancer agents. Generally, GSL-containing plants do not produce CG, vice versa, CG-containing synthesise GSLs. However, the production of both GSL CG compounds was observed Carica papaya. Additionally, several studies found glucotropaeolin prunasin papaya leaves. The advancement g...

Graph Neural Networks (GNNs) have shown promising results on a broad spectrum of applications. Most empirical studies GNNs directly take the observed graph as input, assuming structure perfectly depicts accurate and complete relations between nodes. However, graphs in real-world are inevitably noisy or incomplete, which could even exacerbate quality representations. In this work, we propose nov...

in agricultural meteorology, the growing season is the period within each year when crops can be grown from a view of thermal conditions. this period is in general, between the last and first frost dates in spring and autumn when temperature is above a specific threshold. there are two other definitions when using a 5 °c as threshold. one of the methods employed in studying future climate is us...