Aldehydes, ketones, carboxylic esters, carboxylic amides, imines and N,N-disubstituted hydrazones react as electrophiles at their sp2-hybridized carbon atoms. These compounds also become nucleophiles, if they contain an H atom in the a-position relative to their C O or C N bonds. This is because they can undergo tautomerization to the corresponding enol as seen in Chapter 12. They are also C,H-...

[3H]Forskolin bound to high- and low-affinity sites in the rat brain. The high-affinity site was discretely located, with highest densities in the striatum, nucleus accumbens, olfactory tubercule, substantia nigra, hippocampus, and the molecular layers of the cerebellum. This site did not correlate well with the distribution of adenylate cyclase. The high-affinity striatal binding site may be a...

Administration of the carcinogen ethylene dibromide (EDB) to rats resulted in the urinary excretion of S-[2-(N7-guanyl)ethyl]-N-acetylcysteine, which is derived from the nucleic acid adduct S-[2-(N7-guanyl)ethyl]glutathione. This mercapturic acid was isolated from urine by reversed-phase and propylamino high-performance liquid chromatography and was quantitated by measurement of fluorescence in...

The importance of guanyl nucleotides for calmodulin stimulation of bovine cerebral cortex adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] was examined by using a partially purified calmodulin-sensitive adenylate cyclase that was resolved from calmodulin-insensitive forms of the enzyme. By using 5'-adenylyl imidodiphosphate as a substrate, in the absence of an ATP-regeneratin...

Studies have been made of the effects of nucleotides on binding of 1*61-glucagmm at its specitlc binding sites in plasma membranes of rat Ever. GTP and GDP, equally and at a minimal concentration of 0.05 m, stimulate the rate and degree of dissociation of bound labeled hormone, decrease uptake of glucagon by the membranes, and decrease the aflinity of the binding sites for glucagon. These effec...

a-Acyl-a-cyanocarbonyl-phenylhydrazones are effective uncouplers of oxidative phosphorylation. The p/50-values of a series of 60 hydrazones with substituent variations in six positions of the molecule were determined in rat liver mitochondria. They ranged from 4.96 to 7.06. The biological data together with physico-chemical compound and substituent parameters were analysed by multiple regressio...

The purpose of this work is the synthesis new isonicotinic acid hydrazones, study their structure, reactivity and biological screening some synthesized compounds. reactions leading to N-arylidene(alkylidene) hydrazones via condensation hydrazide with various derivatives aromatic aldehydes were studied. structure functionally substituted was established by FTIR, 1H 13C NMR, two-dimensional COSY ...

Recent advances in electrophilic trifluoromethylation reactions of carbonyl compounds and their usual surrogates are highlighted with particular focus on copper-catalysed (or mediated) C-CF3 bond forming reactions. Ketones and aldehydes (notably via their enol ether and enamine derivatives) enable electrophilic trifluoromethylation at the α-carbon of the carbonyl compounds, whereas aldehyde N,N...