Hypoperfusion to the gut during cardiac arrest is an important clinical problem. The inability to control pH during metabolic stress, e.g. ischemia, leads to the disruption or halting of processes vital to balancing cellular metabolism. Alterations in cellular pH have been linked to changes in intramucosal permeability, which may result in the leakage of inflammatory mediators or bacteria, or b...

BACKGROUND Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both t...

Human monocyte-derived dendritic cells (DC) (MoDC) are utilized for immunotherapy. However, in-vitro immunological effects are often not mirrored in vivo. We studied the tissue-homing potential of MoDC. Circulating monocytes and DC expressed different tissue-homing markers and, during in-vitro development of MoDC, homing marker expression was lost resulting in a 'homeless' phenotype. Retinoic a...

1. Monarch caterpillars, Danaus plexippus (Linnaeus), feed on milkweed plants in the genus Asclepias and sequester cardenolides as an anti-predator defence. However, some predators are able to consume this otherwise unpalatable prey. 2. Chinese mantids, Tenodera sinensis (Saussure), were observed consuming monarch caterpillars by ‘gutting’ them (i.e. removing the gut and associated internal org...

conclusions the results showed that although the human gut microbiome plays a pivotal role in health in a normal concentration, fluctuation in their number (increase or decrease) is a possible factor in the appearance of major diseases. context the composition and function of the gut microbiota develop with their host from birth. the human microbiome, especially the gut microbiota, plays a crit...

Alzheimer’s disease (AD) is a neurodegenerative disease that is the most common type of dementia.AD includes 60_80% of dementia and most people with AD have more than 65 years old.AD causes losing neuronal activity by abnormal proteins. Plaques of beta-amyloid and tangles of “tau” protein can lead to AD. Recently evidence has found that AD may come from outside of central nerv...

Looping of the initially straight embryonic gut tube is an essential aspect of intestinal morphogenesis, permitting proper placement of the lengthy small intestine within the confines of the body cavity. The formation of intestinal loops is highly stereotyped within a given species and results from differential-growth-driven mechanical buckling of the gut tube as it elongates against the constr...

Digestive proteases of the digestive tract of the apple snail Pomacea canaliculata were studied. Luminal protease activity was found in the crop, the style sac and the coiled gut and was significantly higher in the coiled gut. Several protease bands and their apparent molecular weights were identified in both tissue extracts and luminal contents by gel zymography: (1) a 125 kDa protease in sali...

The identification of molecular factors bridging gut microbiota dysbiosis to alterations of host metabolism still remains a major goal in biomedical research. In fact, on one hand, there is a worldwide consensus about the systemic impact, from brain to liver, from heart to adipose tissue, of gut microbiota dysbiosis. On the other hand, beyond the microbial production of short chain fatty acids ...

Breast cancer (BC) impacts 2.3 million women each year, making it the most frequent diagnosed among female population. An unexpected link has been discovered between BC and alterations in mammary gut microbiota, suggesting their possible role development, prevention management. Studies suggest a distinct microbiome healthy breast tissue compared to tissue. The found be mostly enriched with bact...