نتایج جستجو برای: gynecological cancers

تعداد نتایج: 96735  

2014
HIROYUKI MORIYA KATSUHIKO SAITO NUALA HELSBY SHIGEKAZU SUGINO MICHIAKI YAMAKAGE TAKERU SAWAGUCHI MASAHIKO TAKASAKI HIDENORI KATO NAHOKO KUROSAWA

The occurrence of severe neutropenia during treatment with irinotecan (CPT-11) is associated with the *6 and *28 alleles of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). However, the correlation between these variants and the occurrence of severe neutropenia in a low-dose CPT-11 regimen for the treatment of gynecological cancers has not been extensively studied. There are also no st...

Journal: :Annals of research in oncology 2022

The purpose of this study is to systematically review clinical trials on pharmacological therapies for rare gynecological cancers and analyze their characteristics. PRISMA guidelines systematic reviews were followed two databases searched (WHO´s International Clinical Trials Registry Platform clinicaltrials.gov). Jadad score was used assess the methodological quality … Continued

2015
K. M. Chow C. Y. Wong L. L. Shek

Background: According to the World Health Organization, cervical, uterine and ovarian cancers were the third, sixth and eighth most common cancers in women worldwide. Unlike other physiological side effects of cancer treatment, sexual problems in gynecological cancer survivors do not tend to resolve after first few years of cancer treatment. However, women who experience sexual dysfunction do n...

Journal: :Biochimica Et Biophysica Acta - Reviews On Cancer 2021

Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development anti-angiogenesis therapy cancers improvement its efficacy have been a major focus fundamental clinical research. However, survival benefits current anti-angiogenic agents, such as bevacizumab, patients with are modest. Therefore, better understanding angio...

Journal: :European Journal of Gynaecological Oncology 2022

Gynecological cancers (GCs) include cervical, uterine, ovarian, vulvar and vaginal cancer. For women in China, 2 of the 10 most common are GCs (8th: cervical cancer, incidence rate: 3.96%; 10th: ovarian 2.91%). These can lead to enormous psychological economic burdens. Phosphatase tensin homolog (PTEN) gene protein kinase B (AKT) mammalian target rapamycin (mTOR) pathway widely involved develop...

2018
Lei Wang Xing Cheng Wang Xinyu Li Yan Gu Jun Zhou Shuwan Jiang Jiajia Liu Chong Wu Zhiyan Ding Yafeng Wan Chenghai Wang

In recent decades, emerging evidence demonstrates that ultraconserved elements (UCEs) encoding noncoding RNAs serve as regulators of gene expression. Until now, the role of uc.189 in human cancers remains undefined and the clinical significance of uc.189 in gynecological cancers remains unknown. This study was to identify the prognostic value of uc.189 expression in gynecological cancers. Tissu...

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