Hydrogen peroxide (H2O2) as a reactive oxygen species (ROS) plays a crucial role in oxidative stress and signal transduction of organisms. Currently, a fluorescence probe has proven to be a powerful tool for the H2O2 analysis. However, the common problem is the slow response, causing difficulty in tracking H2O2 in situ. Herein, we describe a novel aggregation-induced emission (AIE) fluorescence...

Hydrogen peroxide (H2O2) has established itself as a key player in stress and programmed cell death responses, but little is known about the signaling pathways leading from H2O2 to programmed cell death in plants. Recently, identification of key regulatory mutants and near-full genome coverage microarray analysis of H2O2-induced cell death have begun to unravel the complexity of the H2O2 networ...

Hydrogen peroxide (H2O2) is a relatively long-lived signaling molecule that plays an essential role in oocyte maturation, implantation, as well as early embryonic development. Exposure to relatively high levels of H2O2 functions efficiently to accelerate oocyte aging and deteriorate oocyte quality. However, little precise information exists regarding intra-oocyte H2O2 concentrations, and its di...

Hydrogen peroxide (H2O2) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors. However, these redox targets are orders of magnitude less H2O2-reactive and abundant than cytoplasmic peroxiredoxins. How can they be oxidized in a signaling time frame? Here we invest...

AIM : The aim of this study was to analyse the signalling pathways involved in H2O2 vascular responses in hypertension. METHODS Vascular function, thromboxane A2 (TXA2) production, oxidative stress and protein expression were determined in mesenteric resistance arteries (MRAs) from hypertensive (spontaneously hypertensive rats, SHR) and normotensive Wistar Kyoto (WKY) rats. RESULTS H2O2 and...

Numerous studies have recently provided evidence suggesting an association of cell injury and cell death with reactive oxygen species (ROS). In this study, the cytochemical cerium chloride procedure was used to detect in situ production of hydrogen peroxide (H2O2) in the mouse cumulus oophorus surrounding a postovulatory oocyte. Normal, active cumulus cells showed no presence of H2O2. However, ...