نتایج جستجو برای: haematopoiesis
تعداد نتایج: 658 فیلتر نتایج به سال:
Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Early MAT formation in mice is conserved, whereas later development is strain dependent. Proximal, but not distal tibial, MAT is lost with 21-day c...
Haematopoiesis is one of the most extensively studied models to comprehend cellular differentiation and lineage commitment. It is now well established that blood cells emerge early during vertebrate ontogeny from mesodermal progenitors which also have the potential to generate endothelial and smooth muscle cells. However, the molecular and cellular mechanisms involved in the commitment of mesod...
Efficient production of haematopoietic stem (HPS) cells from embryonic stem (ES) cells or from induced pluripotent stem (iPS) cells requires a thorough understanding of haematopoietic differentiation pathways. On p. 2829, Gordon Keller and colleagues show that generation of HPS cells from ES and iPS cells follows the same steps as haematopoietic development in the embryo. They induced ES cells ...
Haematopoiesis is one of the most extensively studied models to comprehend cellular differentiation and lineage commitment. It is now well established that blood cells emerge early during vertebrate ontogeny from mesodermal progenitors which also have the potential to generate endothelial and smooth muscle cells. However, the molecular and cellular mechanisms involved in the commitment of mesod...
Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration G-CSF would produce accelerated fracture-healing rate non-union bone defects; thus, potentially leading to useful clinical applications. Ten male adult Katjang goats, weig...
The recent description of the placenta as a tissue rich in haematopoietic stem and progenitor cells has not only opened up a whole new line of investigation into how haematopoiesis is regulated in this unique mammalian tissue, but has also resulted in the revisiting of long-standing and yet unanswered questions about the significance of having multiple haematopoietic organs during development. ...
Efficient production of haematopoietic stem (HPS) cells from embryonic stem (ES) cells or from induced pluripotent stem (iPS) cells requires a thorough understanding of haematopoietic differentiation pathways. On p. 2829, Gordon Keller and colleagues show that generation of HPS cells from ES and iPS cells follows the same steps as haematopoietic development in the embryo. They induced ES cells ...
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