BACKGROUND Spontaneous intracerebral haemorrhage is a devastating form of stroke and its incidence increases with age. Obtaining brain tissue following intracerebral haemorrhage helps to understand its cause. Given declining autopsy rates worldwide, the feasibility of establishing an autopsy-based collection and its generalisability are uncertain. METHODS We used multiple overlapping sources ...

BACKGROUND There is a paucity of clinical studies focused specifically on intracerebral haemorrhages of subcortical topography, a subject matter of interest to clinicians involved in stroke management. This single centre, retrospective study was conducted with the following objectives: a) to describe the aetiological, clinical and prognostic characteristics of patients with thalamic haemorrhage...

OBJECTIVES To assess the incidence of gastrointestinal haemorrhage associated with long term aspirin therapy and to determine the effect of dose reduction and formulation on the incidence of such haemorrhage. DESIGN Meta-analysis of 24 randomised controlled trials (almost 66 000 participants). INTERVENTION Aspirin compared with placebo or no treatment, for a minimum of one year. MAIN OUTC...

OBJECTIVE To assess the utilisation, effectiveness, and safety of arterial (angiographic) embolisation for management of severe primary postpartum haemorrhage in Hong Kong public hospitals. DESIGN. Retrospective study. SETTING All eight obstetrics and gynaecology units of the Hospital Authority in Hong Kong. PATIENTS Women who underwent arterial embolisation for primary postpartum haemorrha...

DESCRIPTION A lady in her 50s was transferred to the neurosurgical department with reduced conscious level resulting from subarachnoid haemorrhage. The culpable anterior communicating artery aneurysmwas coiled without complication. The following day she remained drowsy and slightly dysphasic, but intimated a sudden alteration in visual acuity in her right eye. On examination, she was unable to ...

OBJECTIVE To determine the incidence and clinical characteristics of spontaneous haemorrhage into metastatic brain tumours after radiosurgery. METHODS Intratumour haemorrhage rate, clinical features, and treatment were evaluated in 54 patients with 131 brain metastases of varying origin who were treated using linear accelerator radiosurgery. The marginal dose was maintained constant at 20 or ...

BACKGROUND Annually, approximately 1-3% of patients treated with vitamin K antagonists (VKA) suffer from major haemorrhage. Since high levels of free thyroxine (fT4) are associated with increased thrombosis risk, the aim was to assess whether low levels of fT4 contribute to major haemorrhage in patients under VKA treatment. METHODS The FACTORS (Factors in Oral Anticoagulant Safety) study is a...

Two hundred very low birthweight infants were prospectively scanned to ascertain the incidence of periventricular leucomalacia (PVL) and haemorrhage. Before collection of data, clear definitions of ultrasound abnormalities believed to represent PVL and intraventricular haemorrhage were described. These referred to small and moderate intraventricular haemorrhage, paenchymal haemorrhage, and PVL,...

OBJECTIVES The aim was to determine the incidence, causes and the maternal mortality associated with postpartum haemorrhage in a tertiary centre in Nigeria. METHODS Case records of all patients that had postpartum haemorrhage after vaginal delivery at Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife unit over a 5-year period (January 1st, 2002 to December 31st, 2006) were reviewe...