We have known for over 30 years that minoxidil stimulates hair growth, yet our understanding of its mechanism of action on the hair follicle is very limited. In animal studies, topical minoxidil shortens telogen, causing premature entry of resting hair follicles into anagen, and it probably has a similar action in humans. Minoxidil may also cause prolongation of anagen and increases hair follic...

Root hairs provide a model system for the study of cell polarity. We examined the possibility that one or more members of the distinct plant subfamily of RHO monomeric GTPases, termed Rop, may function as molecular switches regulating root hair growth. Specific Rops are known to control polar growth in pollen tubes. Overexpressing Rop2 (Rop2 OX) resulted in a strong root hair phenotype, whereas...

BACKGROUND Cuscuta reflexa (Roxb.), Citrullus colocynthis (Schrad.), and Eclipta alba (Hassk.) are traditionally acclaimed herbs for their hair growth-promoting potential. Aim In the present study, it was envisaged to prepare herbal formulations containing petroleum ether extracts of the three herbs in varying ratio and evaluating the formulations for the hair growth-promoting activity. METHO...

Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to induce entry into anagen. We show that topical treatment of mouse and human ski...

The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-pr...

The pattern of hair growth, morphology of the hair shafts, and the hair root state are described in four girls and two boys with prepubertal hypertrichosis. The exact nosology of this form of excessive hair growth is discussed in relation to hirsuties and the possibility of it representing an 'atavistic' trait.

The hair-growth cycle is an example of a cyclic process that is well characterized morphologically but understood incompletely at the molecular level. As an initial step in discovering regulators in hair-follicle morphogenesis and cycling, we used DNA microarrays to profile mRNA expression in mouse back skin from eight representative time points. We developed a statistical algorithm to identify...

EJD n° 4, vol. 11, July-August 2001 Hair loss or hair thinning is a common complaint in clinical dermatology and patients seeking advice for hair loss are not necessarily bald. In established cases of androgenetic alopecia (AGA) characteristic patterns are easily discernible. However, especially in females the clinician is often challenged by patients with initial stages of AGA where hair loss ...

714 P&T® • December 2005 • Vol. 30 No. 12 NEW DRUGS Eflornithine for Excess Facial Hair in Women Barrier Therapeutics has launched eflornithine HCl cream 13.9% (Vaniqua®) in Canada. The company acquired the exclusive right to distribute this product from Shire in June 2005. This is the only topical prescription product approved by Health Canada for slowing the growth of unwanted facial hair in ...

Sir, An important though rare side effect of reconstruction surgery in oral cavity is persistent hair growth in the recipient site due to intact hair follicles.[1] Hair growth in the transplanted site may be due to the dominant nature of the underlying skin.[2] A 40‐year‐old male came to the dermatology outpatient department with a complaint of excessive hair growth in the oral cavity 2 months ...