Isolated adipocytes from severely diabetic rats exhibited hypersensitivity to epinephrine at low concentrations (0.05-0.1 microM) on lipolysis, compared with isolated adipocytes from normal and mildly diabetic rats. Hypersensitivity to dibutyryl cyclic AMP and theophylline at concentrations from 0.05 to 0.50 mM was not observed in adipocytes of severely diabetic rats. Insulin could not exert an...

Triacylglycerol (TAG) stored in adipose tissue can be rapidly mobilized by the hydrolytic action of lipases, with the release of fatty acids (FA) that are used by other tissues during times of energy deprivation. Unlike synthesis of TAG, which occurs not only in adipose tissue but also in other tissues such as liver for VLDL formation, hydrolysis of TAG, lipolysis, predominantly occurs in adipo...

Summary: The combination of 1320-nm laser lipolysis with lipoaspiration was observed to improve the appearance and contour of the infrachin neck, doubling the improvement seen with prior lipoaspiration performed by identical technique but without the addition of laser lipolysis. This is a preliminary report as to safety of the use of 1320-nm laser lipolysis. No adverse effects were observed in ...

Fibrosis is the pathological accumulation of extracellular matrix and can occur in all soft tissues. In many organs, including skin, fibrosis also associated with a loss fat or lipid-filled cells. dermal adipose tissue has critical roles which are likely impacted by fibrotic remodeling. Despite identifying numerous dysregulated signaling pathways common to disease, mechanism remains poorly unde...

The mechanisms that control lipolysis in intra-abdominal fat cells from various primate species, the marmoset (Callithrix jacchus), the baboon (Papio papio), and the macaque (Macaca fascicularis), were compared to those of human intraabdominal fat cells. Selective beta 1- or beta 2-adrenoceptor agonists induced lipolysis in all species. Selective beta 3-agonists (BRL 37344, CL 316243, and SR 58...

Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obese subjects were incubated with 1) human adiponectin (20 microg/ml) or 2) 0.5 ...

hormone-sensitive lipase, although a role for Ca2+ in some capacity cannot be excluded. The decreased lipolysis cannot be accounted for by a diminished response to cyclic AMP, but the lack of ready reversal of the effects on lipolysis, and the lowering of cell ATP content, suggest that a large part of the effects of both EGTA and ionophore A23 187 on lipolysis may result from damage to fragile ...

Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and cha...

The ability to sense and respond the external environment capacitates tissue stem cells tailor their activity meet organismal needs. It has long been observed in human that irritation leads acquired hypertrichosis, but mechanism remains unclear. We found that, mice, hair follicle (HFSCs) are activated by with prominent regeneration. is not directly sensed HFSCs themselves niche adipocytes which...

Epidemiological and interventional studies have implicated elevated triglyceride-rich lipoprotein (TGRL) levels as a risk factor for cardiovascular disease and vascular inflammation, though the results have not been entirely consistent. This appears particularly relevant in model systems where the lipolysis occurs in the setting of established inflammation (e.g., in pre-existing atherosclerotic...