نتایج جستجو برای: has internalized

تعداد نتایج: 2627024  

Journal: :The Journal of biological chemistry 1984
R Anderson J Niedel

Processing of the formyl peptide receptor by differentiated HL-60 cells has been studied using the photoaffinity label N-formyl-Nle-Leu-Phe-Nle-125I-Tyr-Lys-N epsilon-6-(4'-azido-2' -nitrophenylamino)-hexanoate. The receptor on live cells has an apparent molecular weight of 60,000 to 80,000 and possesses one predominant papain cleavage site on the cell exterior yielding a 35,000-Da fragment tha...

Journal: :Psychiatry research 2014
Branka Aukst-Margetić Nenad Jakšić Vlatka Boričević Maršanić Miro Jakovljević

This study investigated the associations between internalized stigma, depressive symptoms, and temperament dimension Harm avoidance. One hundred and seventeen stable outpatients with schizophrenia completed a battery of self-report instruments. Internalized stigma was significantly positively related to depressive symptoms, while Harm avoidance moderated the internalized stigma-depressive sympt...

Journal: :Infection and immunity 2003
Sean P Nair Markus Bischoff Maria M Senn Brigitte Berger-Bächi

Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does not necessarily account for the differences in the capacities of strains to b...

Journal: :Cell 2016
Alex R.B. Thomsen Bianca Plouffe Thomas J. Cahill Arun K. Shukla Jeffrey T. Tarrasch Annie M. Dosey Alem W. Kahsai Ryan T. Strachan Biswaranjan Pani Jacob P. Mahoney Liyin Huang Billy Breton Franziska M. Heydenreich Roger K. Sunahara Georgios Skiniotis Michel Bouvier Robert J. Lefkowitz

Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor internalization into endosomes. However, it has been demonstrated that some GPCRs activate G proteins from within internalized cellular compartments, resulting in sustained signaling. We have used a variety of biochemi...

Journal: :Journal of neurophysiology 2004
Apostolos Georgopoulos

The problem investigated in this article is at the heart of perceptual-motor control and is centered on the relevance and importance of taking dynamic (kinetic) variables of motion into consideration when intercepting moving targets. The takehome message is that the context of the situation makes all the world’s difference: if you are trying to intercept a falling object, then you definitely re...

Journal: :Postgraduate medical journal 1996
D J Goldsmith I S Roberts N P Mallick

Journal: :Journal of immunology 1998
R L Kitchens R S Munford

We analyzed the impact of ligand aggregation and LPS-induced signaling on CD14-dependent LPS internalization kinetics in human monocytic THP-1 cells and murine macrophages. Using two independent methods, we found that the initial rate and extent of LPS internalization increased with LPS aggregate size. In the presence of LPS binding protein (LBP), large LPS aggregates were internalized extremel...

Journal: :Diabetes 1982
P Gorden J L Carpentier M L Moule C C Yip L Orci

When 125I-insulin is incubated with isolated rodent hepatocytes at 37 degrees C, the ligand initially binds to the plasma membrane of the cell and is subsequently internalized by adsorptive endocytosis. To confirm directly that the insulin receptor is internalized with the ligand, we covalently linked photoreactive 125I-N sigma B29 (azidobenzoyl) insulin to its specific hepatocyte receptor and ...

Objective: The current study was conducted to investigate the role of internalizing and externalizing symptoms and social isolation due to Internet addiction and cyberspace use among teenage girls in 2016-2017 year.  Methods: The research method used in this study was cross-sectional. The study population included all girl students of the second grade public high schools of Tehran city during ...

Journal: :the archives of bone and joint surgery 0
javad parvizi professor of orthopaedic surgery, rothman institute at thomas jefferson university, philadelphia, pa, usa

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