Toxoplasmosis is one of the most common zoonoses worldwide. The seroprevalence for T. gondii in human population from Brazil might range from 40 to 80%. The aim of this paper was to study the seroprevalence of T. gondii infection in children from age one to 15 living in a low socioeconomic community, named community of Jardim São Remo in the year of 2002. The community is located in the West ar...

Aberrant glycosylation is one of the most constant traits of the malignant cell phenotype. To study T-cell responses to tumor-associated glycans, the mouse hemoglobin-derived decapeptide Hb(67-76), which binds well to the MHC class II molecule E(k) and is nonimmunogenic in CBA/J mice, was either O- or N-glycosylated at its primary T-cell receptor contact residue, position 72, with different gly...

background: predicting the incidence of tuberculosis (tb) plays an important role in planning health control strategies for the future, developing intervention programs and allocating resources. objectives: the present longitudinal study estimated the incidence of tuberculosis in 2014 using box-jenkins methods. materials and methods: monthly data of tuberculosis cases recorded in the surveillan...

introduction: glycemia and blood glucose levels are under the effect of hb a1c and therefore they could be considered as a valid index for the follow-up and control of diabetes .there are different and controversial reports on the effects of iron deficiency anemia on hb a1c. effects of ida in non diabetic patients are also unknown. the aim of the study was the comparison of hb a1c levels in hea...

Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was investigated by measurements of delay times and solubilities. In mixtures containing more than 4...

To clarify the role of gammaN-terminal Gly, gamma5 Glu, and gamma143 Ser in 2,3-biphosphosphoglycerate (BPG) binding to fetal hemoglobin (Hb F), we engineered and produced normal human Hb F and two Hb F variants (Hb F gammaG1V, gammaS143H, and Hb F gammaG1V, gammaE5P, gammaS143H) using a yeast expression system and then compared their oxygen-binding properties with those of native human Hb F an...

background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

background: hemoglobin (hb) and hematocrit (hct) have been used routinely in the diagnosis of neonatal anemia and polycythemia.   objective: to measure the cord blood hb and hct and to determine their association with maternal hb and hct.   methods : 170 healthy neonates born through normal vaginal delivery with gestation age of 37-42 wks and birth weight of 2.5-4 kg, and their mothers were inc...

Human hemolysate contains several minor components designated Hb A,,, Hb Alh, Hb A,,, which are post-translational modifications of the major hemoglobin component A,,. Individuals with diabetes mellitus have elevated levels of Hb A,,, a hemoglobin modified with a glucose moiety at the NH, terminus of each /3 chain. A new chromatographic technique using Bio-Rex 70 is described which not only all...

To further understand determinants for Hemoglobin (Hb) S polymerization, as well as the inhibitory mechanism of Hb F on Hb S polymerization, Hb F variants containing Val-* (Hb F yE6V) or Val-*, Thr-y87 (Hb F yE6V. yQ87Tj were expressed in yeast. The oxy form of Hb F yE6V was about 10-fold less stable to mechanical agitation than native oxy Hb F, which is similar to stability differences compari...