OBJECTIVE To investigate the immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines in children with sickle cell disease. DESIGN Open study. SETTING Haemoglobinopathy clinic. SUBJECTS Children with homozygous haemoglobin SS disease (HbSS), sickle haemoglobin C disease (HbSC), and sickle-beta thalassaemia disease (HbS-beta Thal). INTERVENTIONS Children over the age of 2...

Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the relationships between IHD and anemia. In a cluster survey of children 12-59 months of age (n = 291) in Yaoundé and Douala, we assessed hemoglob...

Abbreviation Key HBSS = Hanks balanced salt solution, HPLC = high performance liquid chromatography, IL-2 = interleukin-2, NK = natural killer, SAPLIP = saposin-like protein.

BACKGROUND In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties in attention and processing speed associated with low daytime and night-time oxygen saturation compounded by obstructive sleep apnoea (OSA). In the general population OSA is treated with continuous positive airways pressure (CPAP). The aim of this single-blind, randomised, controlled pha...

The first prerequisite for the efficient and safe exploitation of gas hydrate resources is to accurately analyze primary mechanical performance hydrate-bearing sediments (HBSs). HBSs complex affected by many factors, including reservoir environment in situ (temperature, pore pressure, salinity). Several published studies have demonstrated a correlation behavior hydrates with temperature pressur...

In this study, experimental Ti–6Al–1V–3Fe, Ti–4.5Al–1V–3Fe, and Ti–3Fe alloys, as well commercial Ti–6Al–4V alloy that were scaled up utilizing vacuum induction melting technology, assessed for corrosion performance in simulated body fluids. The selected fluids 0.9 wt% NaCl solution Hanks balanced salt (HBSS). Open circuit potential linear polarization scans performed to understand the of alloy...

Transforming growth factor beta (TGF beta) was examined regarding its regulation of the mitogen EGF. A431 human epidermoid carcinoma cells were treated with TGF beta and epidermal growth factor (EGF) (10 ng/ml each) to determine if TGF beta modulates EGF-induced Ca2+ signaling and c-Fos oncoprotein levels. Changes in [Ca2+]i were determined by digital imaging analysis or photon counting. In HBS...

Statement of the Problem Researchers always seek a new storage medium for avulsed teeth. Castor oil is a vegetable oil with several advantages such as antimicrobial and antioxidant properties, low toxicity, and glutathione preservation capability, low cost, and high availability. Purpose The purpose of this study was to evaluate and compare the capacity of castor oil as a new storage medium i...

This study was performed to test the hypothesis that activated eosinophils or their secretory products can directly stimulate sensory neurons to release their neuropeptides. Neurons derived from neonatal rat dorsal root ganglia (DRG), which synthesize and store sensory neuropeptides, were placed in primary cell culture and were exposed to eosinophils or their bioactive mediators. The resultant ...

Introduction: Tooth avulsion is defined as the complete displacement of the tooth from its alveolar socket which causes damage to the periodontal ligament structure, cementum, alveolar bone, gingiva, and dental pulp. The purpose of this study was to determine the ability of long-shelf life honey milk to serve as a temporary storage medium for the maintenance of periodontal ligament (PDL) cell v...