OBJECTIVE To detect the interactions between six functional polymorphisms in ABCA1 and obesity in Kazakhs with low HDL-C levels. METHODS A total of 204 patients with low HDL-C and 207 health control subjects, which were randomly selected from among 5692 adult Kazakhs, were matched for age and sex. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806...

HDL cholesterol (HDL-C) plasma levels are inversely related to cardiovascular disease risk. Previous studies have shown in animals and humans that HDL promotes regression of atherosclerosis. We hypothesized that this was related to an ability to promote the loss of monocyte-derived cells (CD68(+), primarily macrophages and macrophage foam cells) from plaques. To test this hypothesis, we used an...

High-density lipoprotein (HDL) cholesterol has been known for ages to be cardio-protective due its defensive action against genesis of atherosclerosis. Increasing the serum HDL (HDL-C) as a prospective potential prevent coronary heart disease could not prove beneficial in human trials that put forward major concern about role and functional contribution HDL-C health. Many observational studies ...

Background and objectives: Subclinical thyroid disorder is a most common subclinical disease among many medical conditions such as cardiovascular Lyme disease. The aim of this study was to determine the relationship between lipid profile results, ratios, anthropometric parameters hormones. Methods: One hundred patients (ages 20 50 years) with hypothyroidism (SHT group) healthy subjects (control...

QCD suggests that gluons in the nucleon play an important role in so-called " the proton spin problem ". In this talk, the behavior of the polarized gluon distribution in the nucleon is discussed by using the positivity condition of distribution functions together with the unpolarized and polarized experimental data.

BACKGROUND--Patients with coronary artery disease (CAD) commonly have low HDL cholesterol (HDL-C) and mildly elevated LDL cholesterol (LDL-C), leading to uncertainty as to whether the appropriate goal of therapy should be lowering LDL-C or raising HDL-C. METHODS AND RESULTS--Patients in the Lipoprotein and Coronary Atherosclerosis Study (LCAS) had mildly to moderately elevated LDL-C; many also ...

Background. Niacin is the most effective treatment currently available for raising HDL-C levels. Objective. To evaluate if gender and baseline lipid levels have an effect on the HDL-C response of niacin ER and to identify factors that predict response to niacin ER at the 500 mg dose. Material and Methods. The change in HDL-C effect between baseline and follow-up levels was quantified in absolut...

Abstract Background Research and clinical studies have established a pivotal role of inflammation in the development progression both cardiac vascular diseases, responsive to injurious factors such as smoking, hypertension, dyslipidemia, hyperglycemia. This study analyzed association various lipids, HbA1c glucose with high-sensitivity CRP (hs-CRP), marker low-grade chronic inflammation, communi...