Introduction: Vascular abnormalities are relatively uncommon lesions, but head and neck is a common region for vascular malformation which is classified as benign tumors. In this paper, the authors report a rare presentation of vascular malformation in the tongue and its managements. Case Report: An 18 months 2 old child presented with a giant mass of tongue which caused functional and aesth...

Introduction: Retropharyngeal space schwannomas are rare entities. About 20-45% of schwannomas occur in the head and neck region; however, they represent less than 1% of all head and neck tumors.  Case Report: We present the case of a 36-year-old woman complaining of dysphagia caused by a large schwannoma arising in the posterior pharyngeal wall with remarkable reduction of the oropharyngeal sp...

paragangliomas are neoplasms of neural crest origin. in the head and neck, they uncommonly involve the larynx. the distinction between paragangliomas and other neuroendocrine tumors can be difficult. precise diagnosis is important in order to optimize patient treatment. diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. here we report a 77-year-old woman wi...

Tumor-associated fibroblasts (CAFs) are a significant component of the tumor microenvironment (TME) head and neck squamous cell carcinoma (HNSCC) may stimulate their progression, although exact mechanisms not well understood. This work aimed to establish biologically relevant HNSCC model as basis for further investigations.

Comprehensive identification of potential immune-related genes related to tumor biological behavior and their significance in the treatment head neck squamous cell carcinoma with a messenger RNA (mRNA) vaccine

Resistance to radio and chemotherapy is one of the major drawbacks in the progression of head and neck squamous cell cancer (HNSCC) patients, evidencing the importance of finding optimum molecular prognosis markers to develop personalized treatment schedules. TGF-beta effector TAK1 activity has been related to a greater aggressiveness in several types of cancer (Kondo et al. 1998; Edlund et al....

results of the 53 neck dissection specimens, histopathology showed metastases in 16 cases. the overall accuracy of usgfna, us and palpation was 96%, 68% and 70%, respectively. the specificity of usgfna was superior to palpation and us alone. usgfna had the highest sensitivity, predictive value and accuracy in detecting cervical metastases compared with other performed tests. conclusion in our s...