PURPOSE To analyze the vitreoretinal interface in diabetic eyes using 3-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SSOCT). DESIGN Prospective cross-sectional study. METHODS Fifty-six diabetic patients (88 eyes) and 11 healthy nondiabetic controls (22 eyes) were recruited. Up to 8 SSOCT volumes were acquired for each e...

AIM To find a laboratory indicator for systemic involvement in intermediate uveitis. METHODS Interleukin 8 (IL-8) and C reactive protein (CRP) serum levels were measured in patients with idiopathic intermediate uveitis (n = 61), uveitis controls (n = 143), and normal controls (n = 29). The records of those with intermediate uveitis were reviewed with the emphasis on disease activity and sever...

Methods A prospective controlled observational trial was initiated in female patients and healthy controls aged 12-18 years. Patients and controls were vaccinated (0, 1, and 6 months) and followed for 12 months. HPV16 and 18specific antibody concentrations were measured using a fluorescent microspheres-based multiplex immuno-assay after 12 months. Adverse events (AE’s) 2 weeks after each vaccin...

The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of BPIFB4 and i...

CONTEXT There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD). AIM To determine the vitamin D status of patients with IBD by comparing their serum 25(OH)D concentration to that of healthy controls. HYPOTHESIS Serum 25(OH)D concentration will be lower in patients with IBD compared to controls. SUBJECTS AND METHODS A case-controlled ...

OBJECTIVE To assess dermal expression and fibroblast production of fibrillin-1 (FBN-1) in SSc. METHODS In vivo analysis of microfibrillar network was performed using EM from affected and unaffected skin biopsy specimens of dcSSc patients (n = 5) compared with healthy controls (n = 2). FBN-1 matrix deposition and organization by dermal fibroblast cultures from dcSSc (n = 6), healthy (n = 5) an...

Objective: Cardiac dysfunction has been reported in both cirrhotic and alcoholic patients. Our aim was to determine the relation of serum N-terminal pro-B-type natriuretic peptide (Nt-proBNP) levels myocardial performance index (MPI) disease severity nonalcoholic Patients Methods: In this prospective study including 25 patients 27 healthy controls, MPI assessed by pulsed-wave tissue Doppler ima...

interleukin-8 (il-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. this study investigates il-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the il-8 gene in a pakistani population.patients with acne vulgaris (n=264) and healthy individuals (n=264) were enrolled in this investigation....

background: phototherapy is believed to be a safe method for the management of hyperbilirubinemia. however, there are some controversial issues regarding the genotoxic effects of phototherapy on dna. the aim of this study was to investigate morphologically both phototherapy-induced dna double-strand breaks (dsbs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. me...

• Patients with depression have higher attachment avoidance and anxiety Depression severity correlates the extent of avoidant anxious High is linked to smaller hippocampi parahippocampal cingulum alterations Results suggest a role hippocampal network for Insecure style (anxious avoidant) predisposes development has been in healthy individuals. However, it unclear if there are hippocampus (PHC) ...