Background. Polyethylene glycol, covalently linked to superoxide dismutase (PEG-SOD), has a long plasma half-life (>30 hours) and has been proposed as an effective agent for reducing free radicalmediated injury during ischemia and reperfusion. Methods and Results. Using an isolated rabbit heart perfused with arterial blood from a support rabbit, we have demonstrated that pretreatment with PEG-S...

The objective of this study was to evaluate the effect of dietary supplements with lead acetate and aluminosilicates (ATN) on antioxidative enzyme activities and lipid peroxidation of the heart and skeletal muscle tissues of broiler chickens. Broilers were allotted to four diets including the control group, the Pb group, the aluminosilicate-ATN (antitoxic nutrient) group and the Pb+ATN group, i...

Cardioplegia has become the gold standard of myocardial protection for practically every type of heart surgery during which the ascending aorta must be clamped. Although there is little doubt about the efficacy of cardioplegia in the adult heart, there are few studies on the pediatric heart and their results are contradictory. The physiology of pediatric heart muscle differs considerably from t...

OBJECTIVES To investigate the associations between natural selection to sports at a young age, continuity of physical activity, and occurrence of coronary heart disease. DESIGN Prospective cohort study. SETTING Finland. PARTICIPANTS Former top level male athletes participating at a young age (1920-1965) in different types of sport (endurance (n = 166), power speed (n = 235), "other" (n = ...

background: nowadays use of specific antivenin for latrodectism is considered as the most effective treatment in the world. this study was undertaken to investigate the efficacy of specific antivenom against histopathological complications caused by latrodectus dahli venom on liver, heart and kidneys tissues within 72 h. methods: two groups were selected, each one contained 6 male new zealand r...

IntroductIon “End‐stage heart disease” commonly refers to an irreversible stage of cardiac decompensation caused by a variety of pathologies that cannot be treated using conventional drugs or traditional surgical treatments. The life expectancy of patients with end‐stage heart disease ranges from <6 months to 1 year. Therapeutic strategies for end‐stage heart disease patients are primarily base...

Left ventricular hypertrophy is a maladaptive response to pressure overload and an important risk factor for heart failure. Intermedin (IMD), a multi-functional peptide, plays important roles in cardiovascular protection. In this study, we revealed an autophagy-dependent mechanism involved in IMD's protection against cardiac remodeling and cardiomyocyte death in heart hypertrophy. We observed t...

Cardiovascular diseases are still the main cause of mortality around the world. Therefore, it is essential to develop practical means to reduce their burden. A wealth of evidence supports the role of physical exercise in attenuating many of the risk factors of cardiovascular diseases. Moreover, endurance training warrants protection against myocardial infarction. Exercise, even if performed ...

The role of catecholamines in ischemic preconditioning is unclear. Accordingly, the effects of tyramine-induced norepinephrine release and alpha 1-receptor blockade were examined. Ischemic preconditioning with a 5-minute coronary occlusion 10 minutes before a 30-minute ischemic interval resulted in only 7.7 +/- 3.1% infarction of the risk area, significantly less than that in control rabbits wi...