Heat shock factor 1 (HSF1) is a stress-inducible transcription factor and has been described as a multi-faceted modulator of tumorigenesis. Heat shock, accumulation of misfolded proteins, or malignant transformation promotes the activation and nuclear translocation of HSF1, where it binds to the promoters of heat shock proteins and an array of nonheat shock-regulated proteins to upregulate thei...

This paper proposes a new MINLP model for heat exchanger network synthesis that includes streams with phase change. The model considers every possible combination of process streams that may arise within a chemical process: streams with sensible heat, streams with latent heat, and streams with both latent and sensible heat. As part of the optimization strategy, the superstructure is modeled wit...

introduction: photonics refers to the technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. photonic technology in the meridian and acupoints research has shown the unique advantages, by which the microcosmic material basis and macroscopic phenomena research can be integrated to interpret the occurrence of propagated sensation along me...

We consider the development of implicit-explicit time integration schemes for optimal control problems governed by the Goldstein–Taylor model. In the diffusive scaling this model is a hyperbolic approximation to the heat equation. We investigate the relation of time integration schemes and the formal Chapman-Enskog type limiting procedure. For the class of stiffly accurate implicit–explicit Run...

A systematic method has been developed to study the integration of polygeneration systems in industrial processes and/or urban systems. Several aspects are analyzed with a holistic vision. For given system’s boundaries, the energy services and energy requirements are first characterized. This requires the analysis of the different services and production operations needed. In an industrial proc...

Simultaneous effects of slip and heat transfer on peristaltic transport of an incompressible electrically conducting viscous fluid  in an  asymmetric channel is studied under the assumptions of long wavelength and low Reynold number .The  asymmetry is produced by choosing the peristaltic wave train on the walls to have different amplitudes and phase.Exect solutions for stream function,velocity ...

Multiple sensory cues emanating from humans are thought to guide blood-feeding female mosquitoes to a host. To determine the relative contribution of carbon dioxide (CO2) detection to mosquito host-seeking behavior, we mutated the AaegGr3 gene, a subunit of the heteromeric CO2 receptor in Aedes aegypti mosquitoes. Gr3 mutants lack electrophysiological and behavioral responses to CO2. These muta...

The investigation of a capillary-based heat exchanger is presented for potential integration with thermoelectric devices and thermal energy harvesting. The exchanger is a microfabricated device, designed to promote phase change of low boiling-point working fluids and enhance heat transfer from thermoelectric de-

This work presents a reactive distillation column for the catalytic disproportionation of trichlorosilane to silane which includes three consecutive reversible reactions. This reaction system is however characterized by a large distinction in the boiling points of the components, which make the reactive distillation extremely favored. Nevertheless, the normal reactive distillation column posses...

Butterfly eyespots are complex morphological traits that can vary in size, shape and color composition even on the same wing surface. Homology among eyespots suggests they share a common developmental basis and function as an integrated unit in response to selection. Despite strong evidence of genetic integration, eyespots can also exhibit modularity or plasticity, indicating an underlying flex...