• Microbiota includes commensal and pathogenic microorganisms colonizing human body. Dysbiosis may favour the development of oncologic benign hematologic diseases. Chemotherapy immunesuppression worsen dysbiosis infections. Antibiotic prophylaxis/therapy be detrimental for microbiome composition. Novel target therapies induce possibly impacting on outcome. Growing evidence suggests impact alter...

Since next-generation sequencing has been widely used in clinical laboratories, the diagnosis and risk stratification of hematologic malignancies are greatly dependent on genetic aberrations. In this study, we analyzed genomic landscapes 200 patients with myeloproliferative neoplasms (MPNs) evaluated impact landscape stratification. Mutations JAK2, CALR MPL were detected 76.4% MPNs. The proport...

PURPOSE The European Association of Hematopathologists and the Society for Hematopathology have developed a new World Health Organization (WHO) classification of hematologic malignancies, including lymphoid, myeloid, histiocytic, and mast cell neoplasms. DESIGN Ten committees of pathologists developed lists and definitions of disease entities. A clinical advisory committee (CAC) of internatio...

Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics two different disorders. There are cytopenias and cytoses dysplastic morphology in the circulating blood hyperplastic bone marrow, respectively. Many cytogenetic molecular features have been found this entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not...

Family aggregation of cancer was significantly more common among 588 incident cases with lymphoid neoplasms than among 631 controls (OR: 1.4; 95%CI= 1.1-1.8, p value=0.004). This association was of particular relevance among cases of multiple myeloma and chronic lymphocytic leukemia, with a 2-fold increased risk, the latter also showing an almost 4-fold increased risk of family aggregation of h...

A patient with pulmonary bullae died of massive hemoptysis. At autopsy a hole was observed in the aortic wall. A microscopic examination indicated small Aspergillus lesions in pulmonary bullae and extensive necrotic lesions with Aspergillus hyphae in the media of the thoracic aorta. These findings led to a diagnosis of invasive aspergillosis in the aortic arch. This is a rare case in which Aspe...

Editor, Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin lymphoma (NHL), with a diverse pathobiology while multiple myeloma (MM), a neoplastic disease involving the clonal proliferation of terminally differentiated plasma cells, is the second most common hematologic neoplasm.[1] The simultaneous presentation of these neoplasms is exceedingly rare, and we presen...