نتایج جستجو برای: hemiplegic migraine
تعداد نتایج: 14930 فیلتر نتایج به سال:
Migraine is a neurovascular brain disorder suggested to be due to dysfunction of the trigeminovascular system with sensitization of trigeminal ganglion (TG) nociceptors. Since the neuropeptide calcitonin gene-related peptide (CGRP) has been established as a key player in the pathogenesis of migraine, CGRP receptor antagonists have been considered useful compounds to block headache originating f...
In this issue of Cephalalgia, Dr Jakob Moller Hansen and his colleagues report a series of very interesting experiments in which they successfully induced migraine-like attacks in patients with migraine with aura via infusion of calcitonin gene related peptide (CGRP). This work echoes similar experiments carried out by the Copenhagen group using the nitric oxide donor, glycerol trinitrate (GTN)...
There is a long history associating food allergy with migraine which has been reviewed recently (Monro, 1982). In all, seventeen studies were reported involving investigations on over 1236 patients. The diagnostic methods used to define allergy were mainly elimination diets and challenge and skin tests. Two specific cases, however, are worth emphasizing. Goltman (1936) reported the case of a wo...
Homozygous mutations in SLC4A4, encoding the electrogenic Na(+)-HCO(3)(-) cotransporter NBCe1, have been known to cause proximal renal tubular acidosis (pRTA) and ocular abnormalities. In this study, we report two sisters with pRTA, ocular abnormalities, and hemiplegic migraine. Genetic analysis ruled out pathological mutations in the known genes for familial hemiplegic migraine, but identified...
Dr. Deusvenir de Souza-Carvalho – Rua Pedro de Toledo 980 / 33 04039-002 São Paulo SP Brasil. E-mail: [email protected] According to the second edition of the International Classification of Headache Disorders (ICHD-II), migrainous infarction (MI) is a complication of migraine with aura. MI is diagnosed when one or more aura symptoms last longer than 60 minutes, and neuroradiological stud...
The search for genes involved in the pathophysiology of migraine poses major difficulties. First, there is no objective diagnostic method to assess the status of the individuals studied. Second, migraine is a polygenic multifactorial disorder. Familial hemiplegic migraine (FHM) is the only known autosomal dominant subtype of migraine. In half the families with FHM who have been studied, there a...
Migraine is a common multifactorial episodic brain disorder with strong genetic basis. Monogenic subtypes include rare familial hemiplegic migraine, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, familial advanced sleep-phase syndrome (FASPS), and retinal vasculopathy with cerebral leukodystrophy. Functional studies of disease-causing mutations in ce...
The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed co...
Migraine is a common neurological disorder. It is characterized by recurrent attacks of pulsatile headaches. Data achieved through familial hemiplegic migraine suggest that; mutations in channel proteins can lead dysregulation of calcium and sodium levels and hyperexcitability in nervous system. Even though, genetic tendencies can be responsible for migraine, accumulating data show that many me...
8 ABSTRACT Migraine with aura (MA) is a common headache disorder with a population prevalence of approximately 5%. This subtype of migraine is characterized by neurological, typically visual, symptoms that precede the headache. Twin and family studies have provided strong evidence of genetic factors in MA susceptibility and have shown that the mode ...
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