Regional cerebral blood flow decreases during chronic hyperglycemia, a condition frequently associated with elevated hematocrit. To test the hypothesis that an elevated hematocrit is responsible for the reduced regional cerebral blood flow during chronic hyperglycemia, I used isovolemic hemodilution to normalize the hematocrit in seven normoglycemic and seven streptozotocin-treated (hyperglycem...

schemic stroke involves focal hypoperfusion of the central nervous system. Hemodilution could theoretically improve perfusion to the affected area and, therefore, reduce infarct size. Objective To assess the effects of hemodilution on clinical outcomes in patients with acute ischemic stroke. We also searched trials registers, scanned reference lists, and contacted authors. We included random-iz...

Early in his career, the senior author (RCH) became interested in the experimental study of cerebral vasospasm, which continues to be one of the most important causes of morbidity from subarachnoid hemorrhage (SAH).21–23,45 The initial approach was to find a single pharmacological agent, the so-called “silver bullet,” to prevent and reverse vasospasm. Arterial smooth muscle relaxants were the f...

Our goal was to distinguish the circulatory changes due to acute hypervolemia caused by whole blood and colloid solution from those due to acute hemodilution caused by colloid solution in the conscious rabbit. In six rabbits, homologous whole blood, dextran solution, or modified gelatin solution, equal to 32% of blood volume, was infused over 22 minutes. In six rabbits, 42% of blood volume was ...

STUDY OBJECTIVE To assess the efficacy and safety of hemodilution combined with induced hypotension during surgery. DESIGN Randomized, nonblinded, controlled study. SETTING Operating room suite and intensive care unit (ICU) at a university hospital. PATIENTS 16 ASA physical status I and II patients who underwent general or general plus epidural anesthesia for major orthopedic surgery. I...

Preoperative acute hypervolemic hemodilution (AHHD) is a technique used in anesthesia to reduce the number of blood cells lost during intraoperative bleeding. The aim of the present study was to evaluate the effect of the hypervolemic hemodilution of 6% hydroxyethyl starch 130/0.4 on the EC50 of propofol at two clinical endpoints. A total of 20 patients undergoing AHHD following epidural anesth...

Regional cerebral blood flow decreases during chronic hyperglycemia, a condition frequently associated with elevated hematocrit. To test the hypothesis that an elevated hematocrit is responsible for the reduced regional cerebral blood flow during chronic hyperglycemia, I used isovolemic hemodilution to normalize the hematocrit in seven normoglycemic and seven streptozotocin-treated (hyperglycem...

objective: to investigate the decrease in hemoglobin concentration and hematocrit during elective surgery. methods: this was a prospective study being performed in nemazee hospital of shiraz university of medical sciences. we included a total of 50 american society of anesthesiology (asa) i and ii patients undergoing elective minor surgeries. perioperative fluid administration was performed for...

BACKGROUND AND PURPOSE To evaluate the effects of hemodilution on cerebral hemodynamics and oxygen metabolism in the normal human brain, we measured regional cerebral blood flow, oxygen extraction fraction, oxygen metabolic rate, and regional cerebral blood volume in eight normal volunteers before and after hemodilution using positron emission tomography and oxygen-15-labeled gas inhalation tec...

We studied two young army recruits with erythrocytosis. One had a variant hemoglobin with high affinity for oxygen (hemoglobin Osler, also known as Fort Gordon and Nancy, beta 145 Tyr leads to Asp). The other had normal oxygen affinity and erythrocytosis of undetermined etiology. Both were asymptomatic. We studied exercise capacity on a cycle ergometer before and after hemodilution. In the subj...