Oxygen transport to and substrate turnover in leg muscle were studied at rest and during light and heavy upright bicycle exercise in two brothers with a hereditary hemoglobinopathy associated with high oxygen affinity (P50 = 13 mmHg). Femoral venous oxygen tension was below normal and femoral venous oxygen saturation above normal at rest and during exercise. Thus, the arterial-femoral venous ox...

Ross, JOE M., HILTON M. FAIRCHILD, JOE WELDY, AND ARTHUR C. GUYTON. Autoregulation of blood flow by oxygen lack. Am. J. Physiol. 202(1): 2 r-24. Ig62.-The effect of hemoglobin oxygen saturation upon blood flow through the hind leg of the dog was studied by perfusing the femoral arteries of five normal dogs with blood, the oxygen saturation of which was varied between 100% and o%, and by perfusi...

In reviewing the article “Methemoglobinemia: Sudden Dyspnea and Oxygen Desaturation After Esophagoduodenoscopy,” in the August 2004 issue of RESPIRATORY CARE,1 I found the article suggested that, during the esophagoduodenoscopy procedure the patient’s blood oxygen saturation (measured via pulse oximetry) began to drop rapidly, and a saturation of 54% registered on the pulse oximeter while the p...

Knowledge about the optical properties μa,μs, and g of human blood plays an important role for many diagnostic and therapeutic applications in laser medicine and medical diagnostics. They strongly depend on physiological parameters such as oxygen saturation, osmolarity, flow conditions, haematocrit, etc. The integrating sphere technique and inverse Monte Carlo simulations were applied to measur...

In reviewing the article “Methemoglobinemia: Sudden Dyspnea and Oxygen Desaturation After Esophagoduodenoscopy,” in the August 2004 issue of RESPIRATORY CARE,1 I found the article suggested that, during the esophagoduodenoscopy procedure the patient’s blood oxygen saturation (measured via pulse oximetry) began to drop rapidly, and a saturation of 54% registered on the pulse oximeter while the p...

PURPOSE To evaluate the effects of red blood cell transfusion in patients with SIRS/sepsis who presented hemoglobin levels under 9.0 g/dL at intensive care unit admission, using two parameters of organ perfusion: mixed venous oxygen saturation and serum lactate levels. METHODS All patients admitted to the intensive care unit with SIRS/sepsis, as defined by Consensus Conference in 1992, and he...

A new approach to the spectrophotometric determination of blood oxygen saturation has been made which is based on the absorption maximum of oxyhemoglobin and the isosbestic point of oxyhemoglobin and hemoglobin. The precision of this new method is comparable to that of the manometric procedure in which the Van Slyke-Neil1 apparatus is employed; there is also good correlation between results obt...

BACKGROUND This case conference reviews laboratory methods for assessing oxygenation status: arterial blood gases, pulse oximetry, and CO-oximetry. Caveats of these measurements are discussed in the context of two methemoglobinemia cases. CASES Case 1 is a woman who presented with increased shortness of breath, productive cough, chest pain, nausea, fever, and cyanosis. CO-oximetry indicated a...

An algorithm is introduced for the compensation of the influence of non-haemoglobin absorption as well as tissue scattering on blood spectra used in optical oximetry at the ocular fundus. The in vivo measured spectra were corrected by a linear transformation in order to match the reference spectra of fully oxygenated and reduced blood, respectively, at three isosbestic points (522 nm, 569 nm an...