Dapsone is a commonly used second line drug for prophylaxis of pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients. Oxidant hemolysis, caused by dapsone's metabolite hydroxylamine, is a common side effect, and screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency is recommended before the drug is started in order to prevent potential hemolytic reactions. We report a...

A UTOIMMUNE HEMOLYTIC ANEMIA may complicate a wide variety of diseases, among which are infectious diseases, “collagen” diseases, benign tumors, malignant tumors, lymphomas and Hodgkin’s disease.1’2 The lymphoproliferative disorders, especially chronic lymphatic leukemia, have often been associated with abnormal immunologic mechanisms. The myeloproliferative disorders are rarely associated with...

In this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. Brain MRI demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. The patient was treated with high- dose of Methotrexate. Our re...

Hyperuricemia developed in 2 children with autoimmune hemolytic anemia with reticulocytopenia at a time of hemolytic crisis. One likely cause of hyperuricemia is the destruction of nucleated RBC precursors by autoantibodies. It is advised that patients with autoimmune hemolytic anemia with reticulocytopenia be examined for hyperuricemia. This might explain the reason for reticulocytopenia and m...

BACKGROUND: Hemolytic anemia is a disorder characterized by the premature erythrocytes destruction. Phenylhydrazine (PHZ) induces oxidative stress and reactive oxygen species (ROS) formation, which causes hemolytic anemia. Cynara scolymus due to its antioxidant compounds, has been used for various therapeutic purposes in traditional medicine. OBJECTIVES: The present study was designed to evalua...

INTRODUCTION Mixed warm and cold autoimmune hemolytic anemia runs a chronic course with severe intermittent exacerbations. Therapeutic options for the treatment of hemolysis associated with autoimmune hemolytic anemia are limited. There have been only two reported cases of the effective use of rituximab in the treatment of patients with mixed autoimmune hemolytic anemia. We report a case of sev...

velopment of azathioprine ( Imuran ) , a derivative of 6-mercaptopurine. The efficacy of purine antagonists has been proved in clinical trials by suppression of homograft rejection and autoimmune diseases, particularly autoimmune hemolytic anemia/LlT Several publications deal with the application of this treatment to adults, ’4’1 #{176}’17 but to the best of our knowledge this is the first comm...

Wilson's disease (WD) is a rare inherited disorder of copper metabolism and the main manifestations are liver and brain disorders. Hemolytic anemia is an unusual complication of WD. We describe a 15-year-old girl who developed hemolytic anemia as the first manifestation of Wilson's disease. An Arg952Lys mutation was found in exon 12 of the ATP7B gene, which is uncommon among Chinese Han individ...

By ULFAR JONSSON, M.D., 0. C. HANSEN-PRUSS, M.D., AND R. W. RUNDLES, M.D. T HERE have been many reports in recent years of splenectomy for hemolytic anemia, thrombocytopenia, or pancytopenia resulting from vascular, infectious, or neoplastic involvement of the spleen.” 12, 13, 15 Hemolytic anemia has been observed in a few patients with leukemic splenomegaly) 6. 8. 13, 15 The leukemia has usual...

Auto-immune hemolytic anemia (AIHA) has an extensive differential diagnosis though Hodgkin’s lymphoma (HL) is not always an obvious diagnosis. AIHA can precede the diagnosis of HL for several years. In adults the association of AIHA and HL is more frequent in advanced stages of HL. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a patient wi...