Professor Eberhard F. Mammen greatly contributed to the understanding of the relationship between hemostatic abnormalities and liver diseases. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of the clotting and fibrinolytic systems. Acute or chronic hepatocellular diseases and hepatic failure including l...

OBJECTIVE To analyze our experience and the outcome of operative management of liver trauma, and to suggest ways to improve the management of such patients. METHODS This retrospective study was conducted on patients admitted with liver trauma to King Saud Medical Complex, Riyadh, Kingdom of Saudi Arabia between January 1997 and December 2006. Only patients who underwent operative management w...

Primary postpartum hemorrhage (PPH), defined by the Royal College of Obstetricians and Gynaecologists as bleeding of .500 mL in the first 24 hours of childbirth, complicates 13% of deliveries. Improved awareness, better obstetric care, and involvement of multidisciplinary teams has reduced the incidence of PPH overall, but temporal trends have shown an increase inmajor obstetric hemorrhage. In ...

Clinicians, including anesthesiologists, surgeons, and intensivists, are frequently called on to correct coagulopathy in patients receiving oral anticoagulation therapy. Before elective surgery, anticoagulation reversal may be undertaken over several days by discontinuing warfarin or vitamin K treatment, but rapid correction is required in an emergency. European and American guidelines recommen...

Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies to coagulation FVIII. Bleeding episodes at presentation are spontaneous and severe in most cases. Optimal hemostatic therapy is controversial, and available data are from observational and retrospective studies only. The EACH2 registry, a multicenter, pan-European, Web-based database, reports current patient management. ...

Introduction The coagulation cascade is a dynamic process dependent on many factors. It involves interaction between primary hemostasis, platelet clot formation, secondary hemostasis, thrombin generation, and fibrinolysis. The assessment of this process is particularly important in the surgical patient to properly assess patient coagulation assessment, manage hemostatic therapy and transfusion ...

A 57-year-old man, who was receiving antiplatelet therapy with acetylsalicylic acid for ischemic heart disease and had a recently diagnosed stage IV pulmonary adenocarcinoma (with liver and bone metastases), presented with hemorrhagic shock due to painless hematochezia. Total colonoscopy revealed active bleeding from the ileocecal appendix (▶Fig. 1 a). Initially epinephrine was injected at the ...

BACKGROUND The hemostatic system of children changes with age and differs significantly from the hemostatic system of adults. Age-specific reference values are therefore required for most hemostatic variables. Thromboelastography (TEG) is a point-of-care coagulation test that may provide superior evaluation and management of coagulopathies after cardiac surgery, when large-dose unfractionated h...

One of the most frustrating aspects of making final impressions for crowns and bridges involves the management of finish lines that extend subgingivally. The dentist must contend with many problems like relapsing gingival tissue which can obstruct the flow of impression material into the sulcus. This is most often managed by packing retraction cord which is time-consuming, difficult and often u...