BACKGROUND Few studies have reported the expression of Hepatocyte Paraffin 1 (Hep Par 1) in colorectal carcinomas with contradictory results. Reported rate of expression ranged from 4-50%. Moreover, the correlation between Hep Par 1 expression and clinicopathological parameters has not been investigated. The objective of the present study was to investigate the role of CPS1 (using Hep Par 1) in...

PURPOSE To determine whether an integrin/syndecan-binding domain of fibronectin, called the heparin II (Hep II) domain, affects outflow facility in the human eye. METHODS Anterior segments of human eyes were placed in perfusion organ culture. One eye of each pair received the Hep II domain, and the fellow eye received DMEM or a heat-denatured Hep II domain. The Hep II domain was produced as a...

We discuss hypermultiplets admitting degenerate discrete vacua and BPS domain walls interpolating them. This talk is based on the original papers, hep-th/0307274, hep-th/0211103 and hep-th/0302028. ∗e-mail address: [email protected] †e-mail address: [email protected] Address after December 11: Tokyo Institute of Technology ‡e-mail address: [email protected]

We study metrics on non-compact manifolds with the exceptional holonomy Spin(7), G2. Using the formulation with vector fields, we investigate the metrics with Spin(7) holonomy recently found by Cvetič, Gibbons, Lü and Pope [hep-th/0103155]. Furthermore, we develop the similar formulation for metrics with G2 holonomy. email: [email protected] email: [email protected]...

BACKGROUND The use of herbal preparations (HEP) to alleviate climacteric disorders is expected to increase as women seek alternatives to menopausal hormone therapy to avoid the associated breast cancer risk. Data are sparse on the long-term effects of HEP containing phytoestrogens and black cohosh on breast cancer risk. METHODS Within a German case-control study, associations between patterns...

Herba epimedii (HEP) is one of the most frequently used herbs prescribed for treatment of osteoporosis in China. In the present study, the in vivo effects of HEP extract on bone metabolism were evaluated using 4-month-old ovariectomized (OVX) or sham-operated (Sham) female Sprague-Dawley rats orally administered with HEP extract (110 mg kgd), 17ss-estrogen (2 mg kgd) or its vehicle for 3 months...

Human hepatoma (Hep G2) cells have been shown to secrete nanogram quantities of carboxypeptidase N (Grimwood, B. G., Plummer, T. H., Jr., and Tarentino, A. (1988) J. Biol. Chem. 263, 14397-14401). A second carboxypeptidase with an acidic pH optimum (pH 5.5) is also secreted at levels 2-3-fold greater than carboxypeptidase N. This enzyme was partially purified from the conditioned medium and com...

Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression and even initiation. However, the origins of CAFs in various cancer types remain controversial, and one of the important hypothesized origins is through epithelial-mesenchymal transition (EMT) from cancer cells. In this study, we investigated whether the HEp-2 laryngeal cancer cells are able to generate CAFs via EMT ...

Studies on urban extreme precipitation and its influencing factors are significant for prevention reduction of meteorological disasters; however, few studies focus hourly (HEP) events due to the limitation observation. By using summer data in Beijing from 1980 2020, spatial distribution temporal variation HEP as well local environmental investigated. It is found that both amount frequency affec...

Abstract In many countries, thunderstorms are the main contributor to hourly extreme precipitation (HEP). Prior studies have shown that number of decreased steadily in whole country China; however, HEP has increased significantly several areas over past half-century. The role changes occurrence remains largely unknown China. this study, for first time, we used continuous 32-yr records and thund...