The advantages of the complex recombinant human lactoferrin (rhLF) with europium ions have been used to establish quantitative parameters specific interaction rhLF immobilized heparin-protein conjugate as a model cell-surface heparan sulfate proteoglycans. Heparin coupled through terminal formyl by reductive amination an inert protein was adsorbed part in wells polystyrene microplate. rhLF–Eu3+...

Background: Hemorrhagic events are amongst the major adverse effects of injectable anticoagulants such as heparin and enoxaparin. This necessitates close monitoring of their use for clinically relevant drug-drug interactions. Aim: To study the rate of hemorrhagic events, the anatomical site, and the severity of the hemorrhage in patients receiving heparin or enoxaparin in combination with clop...

dialysis-related amyloidosis (dra) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. in clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (h.m.h. and l.m.h.) have been routinely use...

Marfan syndrome classically presents with aortic root aneurysms. Aortic ectasia causes diverse blood flow alterations, influencing the behavior of coagulation factors and platelet activity. Heparin resistance has also been reported associated Syndrome in a small number patients, probably due to antithrombin III (ATIII) deficiency or various mutations. The ascending aorta valve are replaced pros...

Abstract Anticoagulation strategies for cardiac surgery are witnessing a change with the identification of serious limitations heparin, including development resistance in 3 to 13% patients undergoing and heparin-induced thrombocytopenia/thrombosis syndrome 1 5.5% patients. Heparin alternatives have potential role these scenarios. Bivalirudin, reversible direct thrombin inhibitor, has an onset ...

Heparin-induced thrombocytopenia (GIT) is a paradoxical reaction of platelets to heparin (their aggregation and destruction), potentially dangerous by the development venous arterial thrombosis, less often bleeding. There are serious problems timely diagnosis this complication. They due both insufficient awareness specialists presence negative psychological attitude. The article presents clinic...

Heparin-induced thrombocytopenia (HIT) is a life-threatening, thrombotic disorder associated with development of anti-platelet factor 4 (anti-PF4)/heparin autoantibodies. Little is known about the antigenic and cellular requirements that initiate the immune response to these complexes. To begin to delineate mechanisms of autoantibody formation in HIT, we studied the immunizing effects of murine...