Catheter-related bloodstream infection (CRBSI) is associated with high rates of morbidity. This systematic review assesses the efficacy of antibiotic-based lock solutions to prevent CRBSI. A secondary goal of our review is to determine which antibiotic-based lock solution is most effective in reducing CRBSI. We searched Medline and the Cochrane Library for relevant trials up to April 2009. Data...

heparin- induced thrombocytopenia (hit) is an antibody mediated adverse effect of heparin therapy which is classified into two subtypes, hit i which is non-immune, spontaneously reversible thrombocytopenia and; hit ii which is an autoimmune-mediated adverse effect of heparin therapy. in this case report, we described a 65-year old male patient with hit ii after coronary artery bypass grafting. ...

BACKGROUND Tunnelled central venous dialysis catheter use is significantly limited by the occurrence of catheter-related infections. This randomised controlled trial assessed the efficacy of a 48 hour 70% ethanol lock vs heparin locks in prolonging the time to the first episode of catheter related blood stream infection (CRBSI). METHODS Patients undergoing haemodialysis (HD) via a tunnelled c...

BACKGROUND Catheter infection is a major cause of morbidity and catheter loss in chronic haemodialysis patients. There has been a large discrepancy in the catheter salvage rate, after an episode of documented bacteraemia, whether the patients receive systemic antibiotic alone or systemic antibiotics concomitant with 'antibiotic-lock technique' (20-30% vs 100%, respectively). To test the hypothe...

BACKGROUND Central venous catheters (CVCs) continue to be used at a high rate for dialysis access and are frequently complicated by thrombus-related malfunction. Prophylactic locking with an anticoagulant, such as heparin, has become standard practice despite its associated risks. Trisodium citrate (citrate) 4% is an alternative catheter locking anticoagulant. METHODS The objective was to pro...

BACKGROUND Thrombosis of the central venous haemodialysis catheter compromises dialysis adequacy and catheter survival. Heparin containing catheter-locking solution has been associated with bleeding, interferes with INR (prothrombin time/international normalized ratio) measurements and is costly. Sodium citrate has been used successfully as a catheter-locking solution, but long-term experience ...

BACKGROUND The indwelling venous catheter such as Dual-Cath or Twin-Cath is widely used in haemodialysis. Although the manufacturer recommends filling the catheter lumen with heparin after the dialysis session to prevent clotting, little is known about the systemic effects of such a procedure. METHODS Twenty haemodialysis patients with Dual-Cath were studied. Dialysis anticoagulation was achi...

Infection of central venous catheters used for haemodialysis remains an important cause of morbidity and mortality [1]. Patency of the catheters can be maintained between dialyses by a heparin lock, but this has no antibacterial activity. Sodium citrate, especially at higher concentrations, is an anticoagulant with intrinsic antibacterial activity [2]. However, citrate inadvertently entering th...

BACKGROUND To determine if the catheter lock taurolidine can reduce the number of catheter-related bloodstream infections (CRBSI) in pediatric cancer patients with tunneled central venous catheters (CVC). PROCEDURE During a study period of 34 months, 129 newly placed tunneled CVCs in 112 patients were randomly assigned to standard lock with heparin solution or experimental lock with a tauroli...