BACKGROUND AND AIM: Hepatitis B Virus (HBV), a DNA virus with a human-only reservoir, is a worldwide public health problem. Approximately 45.0% of the world’s population is considered to live in areas of high endemicity with a lifetime risk of infection of more than 60.0%. The present study aimed to assess the level of understanding and awareness about Hepatitis B immunization among the first a...

background and aims: chronic hbv infection is one of the most common viral infections in worldwide which many factors such as genetic factors are involved in pathogenesis of disease. gamma interferon (ifn-γ) and its receptor (infgr) play a critical role in the immune response to hbv infection. single nucleotide polymorphisms (snps) are effective on level of gene expression, the aim of this stud...

introduction: hepatitis b virus (hbv) infection is a serious global public health problem affecting billions of people globally. the lack of information of its seroprevalence among the general population is an obstacle for formulating effective policies to reduce the burden viral hepatitis. therefore, this population based serological survey was conducted in kurdistan province, where no epidemi...

background immune cells and molecules play a vital role in initiating, maintaining, and regulating immunological homeostasis and inflammation in many pathological and physiological processes; however, the changes on expressions and functions of these cells and molecules in hepatitis b virus (hbv) infection has not been elucidated well. conclusions cxcr3-associated chemokines might contribute to...

results genotype b (73.6%) and genotype c (26.4%) were detected in these patients. after treatment for 12 months, the rate of hbv dna seroclearance, alt normalization, and hbeag seroconversion were significantly higher in adv group than in placebo group (p < 0.05). however, there were no significant differences in these three rates between patients infected with genotype b and c (p > 0.05). obj...

results the prevalence of hbsag, hbsab and hbcab were estimated as 0.9%, 30.7% and 10.5%, respectively. the mean age of all participants was 43.9 (95% ci: 43.4, 44.3) in females and 55.6 in (n = 3472) males. in our study, there was a significant association between family history of hepatitis, rural residency and presence of hbsag. there was also a positive correlation between hbcab and family ...

background despite the advances in the treatment of chronic hepatitis b virus (hbv) infection, liver transplantation (lt) remains the only hope for many patients with end-stage liver diseases resulting from hbv. objectives the aim of this study was to investigate the rate of hbv recurrence in cases that had undergone lt due to the hbv related liver cirrhosis. patients and methods forty-nine pat...

conclusions the mutation ratio difference between genotypes b and c in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic hbv genotype c infection associated with higher viral load. objectives the aim of this study was to assess the mutation profiles of bcp and precore regions in different hbv genotypes in chronically infect...

background hepatitis b virus (hbv) covalently closed circular dna (cccdna) served as a vital role in the life cycle of the virus and persistent infection. however, specific and quantitative methods for cccdna detection have not been available. objectives our aim was to develop and primarily evaluate a quantitative method for hbv cccdna based on magnetic capture hybridization and quantitative pc...