Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized liver of patients with chronic liver disease. Fifteen of a total of fifty-eight samples expressed both opioid receptor and methionine enkephal...

BACKGROUND Hepatitis delta virus (HDV) infection results in the most aggressive form of chronic viral hepatitis. There is scarce information about the prevalence, epidemiology, virological profile and natural history of hepatitis delta in HIV patients. METHODS From 16,597 HIV patients enrolled in EuroSIDA, 1319 (7.9%) have ever reported serum hepatitis B virus (HBV) surface antigen (HBsAg)-po...

Hepatitis delta virus (HDV) is the smallest known human and causes most severe form of viral hepatitis, yet it still not fully understood how replicates interacts with many host proteins during replication. This review aims to provide a systematic all factors currently interact HDV their mechanistic involvement in steps replication cycle. Finally, we discuss implications for therapeutic develop...

Background and AimsHepatitis delta virus (HDV) is a defective causes severe liver disease. Several HDV RNA assays have been developed, however the diagnostic efficacy remains unclear.This systematic review meta-analysis aims to evaluate accuracy of aid in diagnosis active hepatitis D.

Antiviral drugs have an established role in the management of selected patients with chronic viral hepatitis. Of the hepatitis viruses (A to E), hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) (also called delta virus) cause chronic hepatitis with the potential for development of cirrhosis and its complications, including primary hepatocellular carcinoma (HCC). HDV ...

The role of active hepatitis B virus (HBV) infection in chronic HBsAg positive hepatitis with and without hepatitis delta virus (HDV) superinfection was analysed in percutaneous liver biopsy specimens from 50 patients. Each specimen was divided into two--one part for histological evaluation and for the detection of HBcAg and delta antigen; the other part was tested for HBV-DNA using Southern bl...