REFERENCES 1. Kosugi C, Furuse J, Ishii H, et al. Needle tract implantation of hepatocellular carcinoma and pancreatic carcinoma after ultrasound-guided percutaneous puncture: clinical and pathologic characteristics and the treatment of needle tract implantation. World J Surg 2004; 28: 29-32. 2. Ishii H, Okada S, Nose H, et al. Local recurrence of hepatocellular carcinoma after percutaneous eth...

Although altered metabolic pathway is an important diagnostic maker and therapeutic target in cancer, it is poorly understood in cancer stem cells (CSCs). Here we show that the CD133 (+) hepatocellular CSCs have distinct metabolic properties, characterized by more active glycolysis over oxidative phosphorylation, compared to the CD133 (-) cells. Inhibition of PDK4 and LDHA markedly suppresses C...

Combined hepatocellular carcinoma and cholangiocarcinoma is found at a frequency of 1.0-6.3% in resected primary hepatic tumors. However, the case of double cancers of hepatocellular carcinoma and cholangiocarcinoma that are discovered synchronously in different lobes of a liver is very rare. We experienced a case of a 74-year-old man who was found to have hepatocellular carcinoma and cholangio...

Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mu...

Introduction. Hepatocellular carcinoma is a serious problem for patients with hemophilia. Hepatitis C virus infection the most common comorbidity in adult inherited bleeding disorders, including Case Report. This case report of 65-year-old male patient hemophilia A and hepatocellular carcinoma. Sorafenib treatment was initiated at dose 400 mg/day, after 50% reduction. In order to prevent episod...

Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such preexisting liver diseases, TGF-b plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial–mesenchymal transition (EMT). TGF-b signaling promotes hepatocellul...

background: telomerase activity increases in cancer cells. bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including hepatocellular carcinoma cells. in this study, an attempt was made to investigate the effects of a new synthetic compound, platinum azidothymidine (pt-azt) on treatment of rats with hepatocellular carcinoma (hcc) and to compare its effects with ...

The study, published in the Journal of Vascular and Interventional Radiology, was focused on investigating TACE with drug-eluting beads (Biocompatibles) in patients with Barcelona Clinic Liver Cancer (BCLC) C stage hepatocellular carcinoma. The recommended treatment for advanced stage hepatocellular carcinoma was systemic therapy. The authors noted that, until the SHARP (Sorafenib hepatocellula...

Thesis Abstract Background: Anti-cancer chemotherapy although effective it inducesserious  adverse effects. In addition, cancer cells can develope resistance to chemotherapy. Aim: The clinical application of cisplatin is limited by severe side effects associated with high applied doses. synergistic effect a combination treatment low dose the natural alkaloid α-solanine on human hepatocellular c...

Hepatocellular carcinoma (HCC) is the most common cancer of digestive system. Recently, transmembrane proteins (TMEMs) have been extensively studied in different types malignant tumors. However, influence TMEM206 hepatocellular unclear. The UALCAN database was used to investigate expression mRNA liver tissues and Human Protein Atlas (THPA) study HCC tissues. measured normal HL-7702 cells HepG2,...