Background/Aim: Salvadora persica is an evergreen shrub or small tree to 6-7m. Fruits have a sweet, agreeable, aromatic, slightly pungent and peppery taste. It has many biological activities such as antipyretic, anti-inflammatory and antifungal activities. This study aims to evaluate cytotoxic effect of Salvadora persica, meswak, (Salvadoraceae) extracts and isolate main compounds from the most...

BACKGROUND Primary hepatocellular carcinoma is one of the most common malignant tumors in China and its mortality rate shows no sign at present of ceasing to rise. In our previous study, we found that the mRNA level of Dynamin3 (DNM3), a member of the Dynamin family, is significantly lower in hepatocellular carcinoma tissues than in non-tumor tissues. The aim of this study was to investigate th...

zn (ii) is an important regulator of caspase-3, as well as an antioxidant, microtubule stabilizer, growth cofactor, and anti-inflammatory agent. over the past 30 years, many researchers have demonstrated the important role of zn (ii) in a variety of physiological processes, including growth and development, maintenance and priming of the immune system, and in tissue repair and regeneration. in ...

objective: this study aimed to evaluate a co-encapsulated pegylated nano-liposome system based on two herbal anti-tumor drugs, silibinin and glycyrrhizic acid, for delivery to a hepatocellular carcinoma (hcc) cell line (hepg2). materials and methods: in this experimental study, co-encapsulated nano-liposomes by the thin layer film hydration method with hepes buffer and sonication at 60% amplitu...

at necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. in solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

conclusions we showed that in treatment of patients with unresectable hepatocellular carcinoma, tace significantly improved the disease and the overall survival rate. also, we introduce the tumor size, serum alp level, and number of liver involved segments as prognostic factors of the procedure. finally, tace can be recommended as the initial treatment for unresectable hcc patients. background ...

7 Abstract 8 miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. Although miR-302b 9 has been suggested to function as a tumor repressor in other cancers, its role in hepatocellular carcinoma is 10 unknown. This study investigated the expression and functional role of miR-302b in human hepatocellular 11 carcinoma. The expression level of miR-302b is dramatica...

medicinal plants have been investigated for possible anti-cancer effects. the aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of hamedan district of iran. the methanolic extracts of the plants were prepared and th...