background & aim:  elevated triglyceride levels in women with hereditary forms of hypertriglyceridemia may involve the risk of pancreatic attacks during pregnancy. case report:in this study, we present the clinical course of a 42-year-old pregnant woman with two vaginal deliveries and one cesarean section (gravidity: 4, parity: 3, live: 2, death: 1) admitted to our hospital. gestational age was...

background periodontitis is a local chronic inflammatory condition of the supporting structures of the teeth resulting from a dental plaque biofilm attached to teeth surfaces. recent studies have indicated that this oral disease may have effects on systemic health. objectives the aim of the present study was to evaluate the association between periodontitis and hyperlipidemia. patients and meth...

The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...

background : lindane is an insecticide which is used in commercial insecticides and food containers. caseâ presentation : herein, we reported on a 62-year-old man with liver cirrhosis 12 years after continuous exposure to lindane gas.the diagnostic workup showed no other possible cause, and findings of liver scintigraphy and clinical manifestations were compatible with substance-induced cirrhos...

background the development of drug delivery systems has improved the therapeutic and toxic properties of existing drugs in therapy. microemulsion systems are novel vehicles for drug delivery, which have been developed in recent years. these systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating ...

BACKGROUND The majority of antiretroviral treatment programmes in sub-Saharan Africa are scaling up antiretroviral treatment using a fixed dose first-line antiretroviral regimen containing stavudine, lamivudine, and nevirapine. One of the primary concerns with the use of this regimen is nevirapine-associated hepatotoxicity. METHODOLOGY/PRINCIPAL FINDINGS Study participants were 1809 HIV-infec...

Background: The risk of hepatotoxicity associated with different HAART regimens (multiple-PI, single-PI or NNRTI-based) in HCV co-infected patients has not been fully assessed. Methods: Retrospective analysis of a prospective cohort of 1,038 HIV/HCV coinfected patients who commenced a new HAART in the Italian MASTER database. Patients were stratified into naïve (N) and experienced (E) to antire...

Herbal hepatotoxicity is a rare and poorly described disease because reported cases are mostly scattered and lack an appropriate causality assessment. We now describe in detail the clinical picture of herbal hepatotoxicity by extracts of Greater Celandine (GC), syn. Chelidonium majus L. from the Papaveraceae family, which contain more than 20 ingredients including various biologically active is...

The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicity. In untreated mice, the amount of hepatic CYP3A11 mRNA is 4-fold greater in PXR(-/-) mice compared to wild-type mice (Guo et al., 2003), a findin...

Herbal hepatotoxicity is a rare but highly disputed disease because numerous confounding variables may complicate accurate causality assessment. Case evaluation is even more difficult when the WHO global introspection method (WHO method) is applied as diagnostic algorithm. This method lacks liver specificity, hepatotoxicity validation, and quantitative items, basic qualifications required for a...