Objective HER-2/neu gene is overexpressed in diverse human cancers and studies suggest a role of its product – p185 protein – in tumor progression by specifically promoting the invasive capacity of tumor cells. Our aim was to evaluate HER-2/neu content in resectable gastric cancer in this geographical region and assess the relationship between p185 expression and clinicopathologic tumor paramet...

Gene expression quantification can be a useful tool in studying the properties of bacterial biofilms. Unfortunately, techniques such as RNA extraction, cDNA synthesis, and quantitative PCR (qPCR) can introduce variability into mRNA transcript measurements, obscuring biologically relevant results. Here we sought to identify the steps that impair accurate gene expression quantification from Staph...

objective: in spite of accumulating information about pathological aspects of sulfur mustard (sm), the precise mechanism responsible for its effects is not well understood. circulating micrornas (mirnas) are promising biomarkers for disease diagnosis and prognosis. accurate normalization using appropriate reference genes, is a critical step in mirna expression studies. in this study, we aimed t...

the construction industry is a major consumer of new materials. given that material production for construction work accounts for a significant percentage of all energy consumed nationally in newly developing countries, it becomes vital that the construction industry strives to reduce waste at all stages of construction. however, the importance of these construction wastes in terms of types and...

comin the case of pharmaceutical processes, the presence of preservatives can be problematic and the quantity is subject to stringent standards. so, the aim of this study is to quantify the removal of glycerin contained in ultrafiltration flat sheet membranes by filtration and soaking. this is carried out over a wide range of membranes with different characteristics. the selected flat sheet mem...

Adoptive immunotherapy involving genetic modification of T cells with antigen-specific, chimeric, singlechain receptors is a promising approach for the treatment of cancer. To determine whether gene-modified T cells could induce antitumor effects without associated autoimmune pathology, we assessed the ability of T cells expressing an anti-Her-2 chimeric receptor to eradicate tumor in Her-2 tra...