7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum MICHX. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein-Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. A...

In this study, the anti-melanogenic effects of Heracleum moellendorffii Hance extract (HmHe) and the mechanisms through which it inhibits melanogenesis in melan-a cells were investigated. Mushroom tyrosinase (TYR) activity and melanin content as well as cellular tyrosinase activity were measured in the cells. mRNA and protein expression of microphthalmia-associated transcription factor (MITF), ...

The essential oil of the root of Heracleum persicum (Apiaceae) was analyzed by capillary GC and GC /MS. The major constituents were identified as viridiflorol (23.05 %), elemol (3.63 %), b-maliene (3.07 %), spathulenol (3.34 %) and 2-tetradecanol (3.38 %).

objective: this study was designed to investigate the effect of hydroalcoholic extract and essential oil of heracleum persicum (apiaceae) on lipid profile of male hyperlipidemic rabbits. materials and methods: thirty rabbits were randomly divided into six groups of five each. one group received normal diet and the other groups fed with a high cholesterol (2% w/w) diet for 7 weeks. vehicle, hydr...

conclusions results of this study suggest that the extract alone of peganum harmala and heracleum persicum may be useful to treat bacterial infections. objectives the major aim of the current study was to investigate the antimicrobial activity of an extract of the peganum harmala flower and heracleum persicum against acinetobacter baumannii. materials and methods the minimum inhibitory (mic) co...

Heracleum siamicum Craib (Apiaceae) is an important herbal spices having a wide applications in flavoring processed foods. The flat-oval shaped fruit of H. siamicum Craib from North Thailand was hydrodistilled and chemical composition of the essential oil was analyzed by GC and GC-MS. The essential oil yield based on dried plant material was 1.25% and twenty-five compounds (corresponding to 97....