Objective(s): In this study, we aimed to evaluate the effect of salidroside on the activities of the different drug-metabolizing enzymes CYP1A2, CYP2B6, CYP2C9, CYP2D6 and CYP3A4 in rats, in which a specific probe drug was used for each enzyme. Materials and Methods: After pretreatment with salidroside, five probe drugs were simultaneously administered to rats by gavage. The given dose was 2.0 ...

Two phenylethanoid glycosides, acteoside and forsythoside B, were first isolated from the traditional Chinese herb Callicarpa peii H.T. Chang. The interaction between the two phenylethanoid glycosides and bovine serum albumin (BSA) was investigated by fluorescence, UV-vis absorbance and circular dichroism (CD). The results showed that the quenching mechanism in the drug-BSA binary systems was a...

Electrochemical oxidation of leaves extract of lemon verbena and the flowers extract of echium amoenum have been studied in the absence and presence of barbituric acid and 1,3 dimethyl barbituric acidin aqueous solutions and biological pH, using cyclic voltammetry method. The results showed that the electrochemically generated compounds in leaves extract of lemon verbena and the flowers extract...

Paullinia cupana is used in weight-loss programs as a constituent of medicinal/dietary supplements. This study aimed to assess a potential herb-drug interaction among a standardized (certified) Paullinia cupana extract and amiodarone (narrow therapeutic index drug) in rats. In a first pharmacokinetic study rats were simultaneously coadministered with a single dose of Paullinia cupana (821 mg/kg...

drug interaction may cause sever adverse drug reactions in patients. the high amounts of prescribed medication in hospitalized patients will cause higher incidence of drug interactions. therefore, the study of drug interactions in hospitalized patients seems to be worth. we have, studied drug interaction in internal and surgical units, in kashani hospital in shahrekord. factors included in this...

BACKGROUND Drug-metabolizing enzymes (DMEs) inhibition based drug-drug interaction and herb-drug interaction severely challenge the R&D process of drugs or herbal ingredients. OBJECTIVE To evaluate the inhibition potential of wogonin (an important flavonoid isolated from the root of Scutellaria baicalensis) towards one of the most important phase II DMEs, UDP-glucuronosyltransferase (UGT) 1A9...