نتایج جستجو برای: hereditary diffuse gastric cancer
تعداد نتایج: 1107433 فیلتر نتایج به سال:
BACKGROUND The cell surface glycoprotein E-cadherin (CDH1) is a key regulator of adhesive properties in epithelial cells. Germline mutations in CDH1 are well established as the defects underlying hereditary diffuse gastric cancer (HDGC) syndrome, and an increased risk of lobular breast cancer (LBC) has been described in HDGC kindreds. However, germline CDH1 mutations have not been described in ...
遺伝性びまん性胃癌は，胃印環細胞癌と乳腺小葉癌を高率発症することを特徴とした常染色体優性遺伝の疾患である．今回，多発びまん性胃癌と乳腺小葉癌の既往から遺伝性びまん性胃癌を疑った症例を経験した．症例は77歳の女性で，45歳時に乳癌の手術歴がある．上部内視鏡検査で幽門前庭部から体中部小彎に多発する褪色調小陥凹を認め，生検で低分化腺癌の診断となり，多発早期胃癌の診断で胃全摘術を施行した．再建時に空腸と肝S3後面に小結節を認め診断目的に切除を行った．病理組織学的検査では胃全域に少なくとも155か所の多発癌を認めた．採取した空腸と肝臓からも同様の腺癌を認め転移と診断した．50歳未満で発症した小葉性乳癌の既往と，特徴的な胃の病理所見から遺伝性びまん性胃癌を疑った．本邦での遺伝性びまん性胃癌の報告は非常に少なく，診断および治療選択の構築と診療体制の整備のため症例集積が望まれる．
BACKGROUND Ten percent of gastric cancer (GC) cases are familial, with one third resulting from a mutation in the tumor suppressor gene CDH1. Loss of this important structure can result in hereditary diffuse gastric cancer (HDGC), which carries a high mortality if early diagnosis is not made. Despite its clear genetic origin, optimal management of HDGC family members is controversial, as the ut...
Diffuse type gastric carcinoma is the most aggressive type of gastric cancer. This type of tumor is not preceded by precancerous changes and is associated with early-onset and hereditary syndromes. To test the hypothesis that DNA methylation profile would be useful for molecular classification of the diffuse type gastric carcinoma, DNA methylation patterns of the CpG Island of 17 genes were stu...
Cancer cells exhibit two opposing methylation abnormalities: genome-wide hypomethylation and gene promoter hypermethylation. Downregulation of E-cadherin (CDH1) plays a key role in the development of diffuse-type gastric cancer, and DNA methylation is a major cause of the gene’s silencing. Hereditary diffuse gastric cancer is caused by germline mutation of CDH1 gene, and DNA methylation frequen...
Hereditary diffuse gastric cancer (HDGC) is a rare cancer susceptibility syndrome. One third of HDGC syndrome families carry germline mutations of the E-cadherin gene. Owing to the limitation of the current endoscopic screening techniques and since no chemoprevention is yet available, total prophylactic gastrectomy is the only option offered to carriers of inactivating mutations in genetic coun...
background the incidence rate of gastric cancer in western countries has shown a remarkable decline in the recent years while it is still the most common cancer among males in iran. the proto-oncogene myc, located at 8q24.1, regulates almost 15% of human genes and is activated in 20% of all tumors. the amplification of myc and overexpression of its protein product are observed in 15 - 30% of ga...
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